Catastrophic Intracranial Hemorrhages after IV tPA in a Patient with Insidious Onset of Fever and Back Pain

Steven Tversky, Richard B. Libman, Evan R. Schloss, Rohan Arora, Anand V. Patel, Elliot J. Salamon, Paul Wright, Jeffrey M. Katz

Research output: Contribution to journalArticle

5 Scopus citations


Infective endocarditis is associated with unstable infective vegetations, which have a propensity to embolize and cause embolic events, such as stroke. Many cases present with an embolic event as the first sign of infective endocarditis. We present a patient who had a history of recent and persistent fever, an acute ischemic stroke treated with intravenous tissue plasminogen activator (IV tPA), and severe, multifocal intracerebral hemorrhage as a complication of tPA treatment. Suspected infective endocarditis in a stroke patient should most likely be considered a contraindication to IV tPA.

Original languageEnglish (US)
Pages (from-to)e69-e70
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number5
StatePublished - May 1 2016
Externally publishedYes



  • endocarditis
  • infectious disease
  • septic emboli
  • Stroke
  • tPA

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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