Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: Effects of somatostatin

D. E. Potter, J. W. Barnett, L. C. Woodson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The present study was conducted to determine if glucagon release is involved in the hyperglycemic response to epinephrine and isoproterenol in the fasted and fed, unanesthetized rabbit. Epinephrine produced dose-related increases in plasma glucose and glucagon levels in fed and fasted rabbits whereas isoprotereol produced modest hyperglycemia without hyperglucagonemia. Infusion of somatostatin suppressed epinephrine-induced glucagon release and this was correlated with a 50% reduction in the hyperglycemic response. These data suggest that epinephrine-induced glucagon release is the primary reason for the difference in hyperglycemic activity between epinephrine and isoproterenol in the unanesthetized rabbit.

Original languageEnglish (US)
Pages (from-to)373-377
Number of pages5
JournalHormone and Metabolic Research
Issue number5
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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