Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: Effects of somatostatin

D. E. Potter, J. W. Barnett, L. C. Woodson

    Research output: Contribution to journalArticle

    5 Scopus citations

    Abstract

    The present study was conducted to determine if glucagon release is involved in the hyperglycemic response to epinephrine and isoproterenol in the fasted and fed, unanesthetized rabbit. Epinephrine produced dose-related increases in plasma glucose and glucagon levels in fed and fasted rabbits whereas isoprotereol produced modest hyperglycemia without hyperglucagonemia. Infusion of somatostatin suppressed epinephrine-induced glucagon release and this was correlated with a 50% reduction in the hyperglycemic response. These data suggest that epinephrine-induced glucagon release is the primary reason for the difference in hyperglycemic activity between epinephrine and isoproterenol in the unanesthetized rabbit.

    Original languageEnglish (US)
    Pages (from-to)373-377
    Number of pages5
    JournalHormone and Metabolic Research
    Volume10
    Issue number5
    DOIs
    StatePublished - Jan 1 1978

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    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Biochemistry
    • Endocrinology
    • Clinical Biochemistry
    • Biochemistry, medical

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