Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: Effects of somatostatin

D. E. Potter; J. W. Barnett; L. C. Woodson

doi:10.1055/s-0028-1093394

Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: Effects of somatostatin

D. E. Potter, J. W. Barnett, L. C. Woodson

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The present study was conducted to determine if glucagon release is involved in the hyperglycemic response to epinephrine and isoproterenol in the fasted and fed, unanesthetized rabbit. Epinephrine produced dose-related increases in plasma glucose and glucagon levels in fed and fasted rabbits whereas isoprotereol produced modest hyperglycemia without hyperglucagonemia. Infusion of somatostatin suppressed epinephrine-induced glucagon release and this was correlated with a 50% reduction in the hyperglycemic response. These data suggest that epinephrine-induced glucagon release is the primary reason for the difference in hyperglycemic activity between epinephrine and isoproterenol in the unanesthetized rabbit.

Original language	English (US)
Pages (from-to)	373-377
Number of pages	5
Journal	Hormone and Metabolic Research
Volume	10
Issue number	5
DOIs	https://doi.org/10.1055/s-0028-1093394
State	Published - Jan 1 1978

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

Access to Document

10.1055/s-0028-1093394

Cite this

@article{0c5edb1dd8d04e21a7ef4a2499ea3c1c,

title = "Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: Effects of somatostatin",

abstract = "The present study was conducted to determine if glucagon release is involved in the hyperglycemic response to epinephrine and isoproterenol in the fasted and fed, unanesthetized rabbit. Epinephrine produced dose-related increases in plasma glucose and glucagon levels in fed and fasted rabbits whereas isoprotereol produced modest hyperglycemia without hyperglucagonemia. Infusion of somatostatin suppressed epinephrine-induced glucagon release and this was correlated with a 50% reduction in the hyperglycemic response. These data suggest that epinephrine-induced glucagon release is the primary reason for the difference in hyperglycemic activity between epinephrine and isoproterenol in the unanesthetized rabbit.",

author = "Potter, {D. E.} and Barnett, {J. W.} and Woodson, {L. C.}",

year = "1978",

month = jan,

day = "1",

doi = "10.1055/s-0028-1093394",

language = "English (US)",

volume = "10",

pages = "373--377",

journal = "Hormone and Metabolic Research",

issn = "0018-5043",

publisher = "Georg Thieme Verlag",

number = "5",

}

TY - JOUR

T1 - Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits

T2 - Effects of somatostatin

AU - Potter, D. E.

AU - Barnett, J. W.

AU - Woodson, L. C.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - The present study was conducted to determine if glucagon release is involved in the hyperglycemic response to epinephrine and isoproterenol in the fasted and fed, unanesthetized rabbit. Epinephrine produced dose-related increases in plasma glucose and glucagon levels in fed and fasted rabbits whereas isoprotereol produced modest hyperglycemia without hyperglucagonemia. Infusion of somatostatin suppressed epinephrine-induced glucagon release and this was correlated with a 50% reduction in the hyperglycemic response. These data suggest that epinephrine-induced glucagon release is the primary reason for the difference in hyperglycemic activity between epinephrine and isoproterenol in the unanesthetized rabbit.

AB - The present study was conducted to determine if glucagon release is involved in the hyperglycemic response to epinephrine and isoproterenol in the fasted and fed, unanesthetized rabbit. Epinephrine produced dose-related increases in plasma glucose and glucagon levels in fed and fasted rabbits whereas isoprotereol produced modest hyperglycemia without hyperglucagonemia. Infusion of somatostatin suppressed epinephrine-induced glucagon release and this was correlated with a 50% reduction in the hyperglycemic response. These data suggest that epinephrine-induced glucagon release is the primary reason for the difference in hyperglycemic activity between epinephrine and isoproterenol in the unanesthetized rabbit.

UR - http://www.scopus.com/inward/record.url?scp=0018119582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018119582&partnerID=8YFLogxK

U2 - 10.1055/s-0028-1093394

DO - 10.1055/s-0028-1093394

M3 - Article

C2 - 361531

AN - SCOPUS:0018119582

SN - 0018-5043

VL - 10

SP - 373

EP - 377

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

IS - 5

ER -

Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: Effects of somatostatin

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this