Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis

Huan Yang, Mrinalini Kala, Benjamin G. Scott, Elzbieta Goluszko, Harold A. Chapman, Premkumar Christadoss

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Because presentation of acetylcholine receptor (AChR) peptides to T cells is critical to the development of myasthenia gravis, we examined the role of cathepsin S (Cat S) in experimental autoimmune myasthenia gravis (EAMG) induced by AChR immunization. Compared with wild type, Cat S null mice were markedly resistant to the development of EAMG, and showed reduced T and B cell responses to AChR. Cat S null mice immunized with immunodominant AChR peptides showed weak responses, indicating failed peptide presentation accounted for autoimmune resistance. A Cat S inhibitor suppressed in vitro IFN-† production by lymph node cells from AChR-immunized, DR3-bearing transgenic mice. Because Cat S null mice are not severely immunocompromised, Cat S inhibitors could be tested for their therapeutic potential in EAMG.

Original languageEnglish (US)
Pages (from-to)1729-1737
Number of pages9
JournalJournal of Immunology
Volume174
Issue number3
StatePublished - Feb 1 2005

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cathepsin S
Myasthenia Gravis
Cholinergic Receptors
Autoimmune Experimental Myasthenia Gravis
Peptide T
T-Lymphocytes
Peptides
Transgenic Mice
Immunization
B-Lymphocytes
Lymph Nodes

ASJC Scopus subject areas

  • Immunology

Cite this

Yang, H., Kala, M., Scott, B. G., Goluszko, E., Chapman, H. A., & Christadoss, P. (2005). Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. Journal of Immunology, 174(3), 1729-1737.

Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. / Yang, Huan; Kala, Mrinalini; Scott, Benjamin G.; Goluszko, Elzbieta; Chapman, Harold A.; Christadoss, Premkumar.

In: Journal of Immunology, Vol. 174, No. 3, 01.02.2005, p. 1729-1737.

Research output: Contribution to journalArticle

Yang, H, Kala, M, Scott, BG, Goluszko, E, Chapman, HA & Christadoss, P 2005, 'Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis', Journal of Immunology, vol. 174, no. 3, pp. 1729-1737.
Yang H, Kala M, Scott BG, Goluszko E, Chapman HA, Christadoss P. Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. Journal of Immunology. 2005 Feb 1;174(3):1729-1737.
Yang, Huan ; Kala, Mrinalini ; Scott, Benjamin G. ; Goluszko, Elzbieta ; Chapman, Harold A. ; Christadoss, Premkumar. / Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. In: Journal of Immunology. 2005 ; Vol. 174, No. 3. pp. 1729-1737.
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