Causes and consequences of flavivirus RNA methylation

Shelton S. Bradrick

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations

Abstract

Mosquito-borne flaviviruses are important human pathogens that represent global threats to human health. The genomes of these positive-strand RNA viruses have been shown to be substrates of both viral and cellular methyltransferases. N7-methylation of the 5' cap structure is essential for infection whereas 2'-O-methylation of the penultimate nucleotide is required for evasion of host innate immunity. N6-methylation of internal adenosine nucleotides has also been shown to impact flavivirus infection. Here, I summarize recent progress made in understanding roles for methylation in the flavivirus life-cycle and discuss relevant emerging hypotheses.

Original languageEnglish (US)
Article number2374
JournalFrontiers in Microbiology
Volume8
Issue numberDEC
DOIs
StatePublished - Dec 5 2017

Keywords

  • Dengue virus
  • Flavivirus
  • Hepatitis C virus
  • Methylation
  • Zika virus

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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