Causes and consequences of flavivirus RNA methylation

Shelton Bradrick

Research output: Contribution to journalShort survey

5 Citations (Scopus)

Abstract

Mosquito-borne flaviviruses are important human pathogens that represent global threats to human health. The genomes of these positive-strand RNA viruses have been shown to be substrates of both viral and cellular methyltransferases. N7-methylation of the 5' cap structure is essential for infection whereas 2'-O-methylation of the penultimate nucleotide is required for evasion of host innate immunity. N6-methylation of internal adenosine nucleotides has also been shown to impact flavivirus infection. Here, I summarize recent progress made in understanding roles for methylation in the flavivirus life-cycle and discuss relevant emerging hypotheses.

Original languageEnglish (US)
Article number2374
JournalFrontiers in Microbiology
Volume8
Issue numberDEC
DOIs
StatePublished - Dec 5 2017

Fingerprint

Flavivirus
Methylation
RNA
Flavivirus Infections
Nucleotides
RNA Viruses
Methyltransferases
Life Cycle Stages
Culicidae
Innate Immunity
Adenosine
Genome
Health
Infection

Keywords

  • Dengue virus
  • Flavivirus
  • Hepatitis C virus
  • Methylation
  • Zika virus

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Causes and consequences of flavivirus RNA methylation. / Bradrick, Shelton.

In: Frontiers in Microbiology, Vol. 8, No. DEC, 2374, 05.12.2017.

Research output: Contribution to journalShort survey

Bradrick, Shelton. / Causes and consequences of flavivirus RNA methylation. In: Frontiers in Microbiology. 2017 ; Vol. 8, No. DEC.
@article{b5d32caed4504293b43b97f76b1c2e7b,
title = "Causes and consequences of flavivirus RNA methylation",
abstract = "Mosquito-borne flaviviruses are important human pathogens that represent global threats to human health. The genomes of these positive-strand RNA viruses have been shown to be substrates of both viral and cellular methyltransferases. N7-methylation of the 5' cap structure is essential for infection whereas 2'-O-methylation of the penultimate nucleotide is required for evasion of host innate immunity. N6-methylation of internal adenosine nucleotides has also been shown to impact flavivirus infection. Here, I summarize recent progress made in understanding roles for methylation in the flavivirus life-cycle and discuss relevant emerging hypotheses.",
keywords = "Dengue virus, Flavivirus, Hepatitis C virus, Methylation, Zika virus",
author = "Shelton Bradrick",
year = "2017",
month = "12",
day = "5",
doi = "10.3389/fmicb.2017.02374",
language = "English (US)",
volume = "8",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S. A.",
number = "DEC",

}

TY - JOUR

T1 - Causes and consequences of flavivirus RNA methylation

AU - Bradrick, Shelton

PY - 2017/12/5

Y1 - 2017/12/5

N2 - Mosquito-borne flaviviruses are important human pathogens that represent global threats to human health. The genomes of these positive-strand RNA viruses have been shown to be substrates of both viral and cellular methyltransferases. N7-methylation of the 5' cap structure is essential for infection whereas 2'-O-methylation of the penultimate nucleotide is required for evasion of host innate immunity. N6-methylation of internal adenosine nucleotides has also been shown to impact flavivirus infection. Here, I summarize recent progress made in understanding roles for methylation in the flavivirus life-cycle and discuss relevant emerging hypotheses.

AB - Mosquito-borne flaviviruses are important human pathogens that represent global threats to human health. The genomes of these positive-strand RNA viruses have been shown to be substrates of both viral and cellular methyltransferases. N7-methylation of the 5' cap structure is essential for infection whereas 2'-O-methylation of the penultimate nucleotide is required for evasion of host innate immunity. N6-methylation of internal adenosine nucleotides has also been shown to impact flavivirus infection. Here, I summarize recent progress made in understanding roles for methylation in the flavivirus life-cycle and discuss relevant emerging hypotheses.

KW - Dengue virus

KW - Flavivirus

KW - Hepatitis C virus

KW - Methylation

KW - Zika virus

UR - http://www.scopus.com/inward/record.url?scp=85036641402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85036641402&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2017.02374

DO - 10.3389/fmicb.2017.02374

M3 - Short survey

AN - SCOPUS:85036641402

VL - 8

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

IS - DEC

M1 - 2374

ER -