Abstract
Recently we proposed to use laser- and ultrasound-induced cavitation to enhance delivery of anti-cancer agents from blood into tumor cells through tumor capillary wall, interstitium, and cancer cell membrane. Cavitation threshold can be lowered by using microparticles (with certain optical and acoustic properties) which can accumulate in tumors after injection in blood. Lower cavitation threshold allows for local and pronounced cavitation in tumors and, therefore, may provide safe and efficient delivery of anti-cancer drugs in cancer cells without damage to normal tissues by laser or ultrasound radiation. In this paper, we studied enhanced penetration of model macromolecular (rhodamine-dextran) and real anti-cancer (5-FU) drugs and efficacy of cancer therapy with the use of this technique in nude mice bearing human colon tumors KM20. Our studies showed enhanced penetration of the drugs in irradiated tumors and significant improvement of cancer therapy when radiation was applied in combination with polystyrene particle and 5-FU injections. Complete tumor regression of irradiated tumors was obtained when optimum conditions were used. Our results suggest that this technique can potentially be used for efficient and safe cancer chemotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 393-397 |
| Number of pages | 5 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 4257 |
| DOIs | |
| State | Published - 2001 |
| Event | Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical - San Jose, CA, United States Duration: Jan 21 2001 → Jan 24 2001 |
Keywords
- Cancer therapy
- Cavitation
- Colon tumor
- Interstitium
- Ultrasound
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering