Cavitation-induced drug delivery in tumors for cancer chemotherapy

Animal studies

Rinat Esenaliev, I. Larina, Y. Ivanova, T. Ashitkov, R. Thomas, M. Evers

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Recently we proposed to use laser- and ultrasound-induced cavitation to enhance delivery of anti-cancer agents from blood into tumor cells through tumor capillary wall, interstitium, and cancer cell membrane. Cavitation threshold can be lowered by using microparticles (with certain optical and acoustic properties) which can accumulate in tumors after injection in blood. Lower cavitation threshold allows for local and pronounced cavitation in tumors and, therefore, may provide safe and efficient delivery of anti-cancer drugs in cancer cells without damage to normal tissues by laser or ultrasound radiation. In this paper, we studied enhanced penetration of model macromolecular (rhodamine-dextran) and real anti-cancer (5-FU) drugs and efficacy of cancer therapy with the use of this technique in nude mice bearing human colon tumors KM20. Our studies showed enhanced penetration of the drugs in irradiated tumors and significant improvement of cancer therapy when radiation was applied in combination with polystyrene particle and 5-FU injections. Complete tumor regression of irradiated tumors was obtained when optimum conditions were used. Our results suggest that this technique can potentially be used for efficient and safe cancer chemotherapy.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsD.D. Duncan, S.L. Jacques, P.C. Johnson
Pages393-397
Number of pages5
Volume4257
DOIs
StatePublished - 2001
EventLaser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical - San Jose, CA, United States
Duration: Jan 21 2001Jan 24 2001

Other

OtherLaser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical
CountryUnited States
CitySan Jose, CA
Period1/21/011/24/01

Fingerprint

Chemotherapy
chemotherapy
cavitation flow
Drug delivery
Cavitation
animals
Tumors
delivery
Animals
drugs
tumors
cancer
blood
Blood
Bearings (structural)
penetration
Ultrasonics
Cells
injection
Acoustic properties

Keywords

  • Cancer therapy
  • Cavitation
  • Colon tumor
  • Interstitium
  • Ultrasound

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Esenaliev, R., Larina, I., Ivanova, Y., Ashitkov, T., Thomas, R., & Evers, M. (2001). Cavitation-induced drug delivery in tumors for cancer chemotherapy: Animal studies. In D. D. Duncan, S. L. Jacques, & P. C. Johnson (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4257, pp. 393-397) https://doi.org/10.1117/12.434726

Cavitation-induced drug delivery in tumors for cancer chemotherapy : Animal studies. / Esenaliev, Rinat; Larina, I.; Ivanova, Y.; Ashitkov, T.; Thomas, R.; Evers, M.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / D.D. Duncan; S.L. Jacques; P.C. Johnson. Vol. 4257 2001. p. 393-397.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Esenaliev, R, Larina, I, Ivanova, Y, Ashitkov, T, Thomas, R & Evers, M 2001, Cavitation-induced drug delivery in tumors for cancer chemotherapy: Animal studies. in DD Duncan, SL Jacques & PC Johnson (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4257, pp. 393-397, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical, San Jose, CA, United States, 1/21/01. https://doi.org/10.1117/12.434726
Esenaliev R, Larina I, Ivanova Y, Ashitkov T, Thomas R, Evers M. Cavitation-induced drug delivery in tumors for cancer chemotherapy: Animal studies. In Duncan DD, Jacques SL, Johnson PC, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4257. 2001. p. 393-397 https://doi.org/10.1117/12.434726
Esenaliev, Rinat ; Larina, I. ; Ivanova, Y. ; Ashitkov, T. ; Thomas, R. ; Evers, M. / Cavitation-induced drug delivery in tumors for cancer chemotherapy : Animal studies. Proceedings of SPIE - The International Society for Optical Engineering. editor / D.D. Duncan ; S.L. Jacques ; P.C. Johnson. Vol. 4257 2001. pp. 393-397
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