Cavitation-induced drug delivery in tumors for cancer chemotherapy: Phantom studies

I. Larina, C. Bartels, K. Larin, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

One of the major problems of cancer chemotherapy is slow diffusion of anti-cancer drugs in the interstitium and their poor penetration from blood through tumor capillary wall and cancer cell membrane. To enhance delivery of the drugs in cancer cells we proposed to use interaction of exogenous microparticles with laser or ultrasonic radiation. This interaction results in cavitation near the particles upon certain irradiation conditions. Our previous pilot studies demonstrated feasibility of enhanced delivery of model and real anti-cancer drugs in tissues in vitro and in vivo if laser pulsed or ultrasonic radiation is applied. In this work we performed studies in tissue phantoms in order to find optimal parameters that can be used for safe and efficient delivery of anti-cancer drugs in tumors. Water solutions and gelatin were used as tissue phantoms with well-controlled parameters. Cavitation in the phantoms was studied by using optical and ultrasound techniques. Results of our studies indicate that efficient cavitation-driven drug delivery can be achieved with no or minimal damage to normal tissues.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsD.D. Duncan, S.L. Jacques, P.C. Johnson
Pages385-392
Number of pages8
Volume4257
DOIs
StatePublished - 2001
EventLaser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical - San Jose, CA, United States
Duration: Jan 21 2001Jan 24 2001

Other

OtherLaser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical
CountryUnited States
CitySan Jose, CA
Period1/21/011/24/01

Fingerprint

Chemotherapy
chemotherapy
cavitation flow
Drug delivery
Cavitation
Tumors
delivery
drugs
tumors
cancer
Tissue
Ultrasonics
ultrasonic radiation
Radiation
Cell membranes
Pulsed lasers
pulsed radiation
Blood
Cells
gelatins

Keywords

  • Anti-cancer drug
  • Cavitation
  • Laser
  • Tumor
  • Ultrasound

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Larina, I., Bartels, C., Larin, K., & Esenaliev, R. (2001). Cavitation-induced drug delivery in tumors for cancer chemotherapy: Phantom studies. In D. D. Duncan, S. L. Jacques, & P. C. Johnson (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4257, pp. 385-392) https://doi.org/10.1117/12.434724

Cavitation-induced drug delivery in tumors for cancer chemotherapy : Phantom studies. / Larina, I.; Bartels, C.; Larin, K.; Esenaliev, Rinat.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / D.D. Duncan; S.L. Jacques; P.C. Johnson. Vol. 4257 2001. p. 385-392.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Larina, I, Bartels, C, Larin, K & Esenaliev, R 2001, Cavitation-induced drug delivery in tumors for cancer chemotherapy: Phantom studies. in DD Duncan, SL Jacques & PC Johnson (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4257, pp. 385-392, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical, San Jose, CA, United States, 1/21/01. https://doi.org/10.1117/12.434724
Larina I, Bartels C, Larin K, Esenaliev R. Cavitation-induced drug delivery in tumors for cancer chemotherapy: Phantom studies. In Duncan DD, Jacques SL, Johnson PC, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4257. 2001. p. 385-392 https://doi.org/10.1117/12.434724
Larina, I. ; Bartels, C. ; Larin, K. ; Esenaliev, Rinat. / Cavitation-induced drug delivery in tumors for cancer chemotherapy : Phantom studies. Proceedings of SPIE - The International Society for Optical Engineering. editor / D.D. Duncan ; S.L. Jacques ; P.C. Johnson. Vol. 4257 2001. pp. 385-392
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