Cavitation-induced drug delivery in tumors for cancer chemotherapy: Phantom studies

I. Larina, C. Bartels, K. Larin, R. Esenaliev

Research output: Contribution to journalConference article

6 Scopus citations

Abstract

One of the major problems of cancer chemotherapy is slow diffusion of anti-cancer drugs in the interstitium and their poor penetration from blood through tumor capillary wall and cancer cell membrane. To enhance delivery of the drugs in cancer cells we proposed to use interaction of exogenous microparticles with laser or ultrasonic radiation. This interaction results in cavitation near the particles upon certain irradiation conditions. Our previous pilot studies demonstrated feasibility of enhanced delivery of model and real anti-cancer drugs in tissues in vitro and in vivo if laser pulsed or ultrasonic radiation is applied. In this work we performed studies in tissue phantoms in order to find optimal parameters that can be used for safe and efficient delivery of anti-cancer drugs in tumors. Water solutions and gelatin were used as tissue phantoms with well-controlled parameters. Cavitation in the phantoms was studied by using optical and ultrasound techniques. Results of our studies indicate that efficient cavitation-driven drug delivery can be achieved with no or minimal damage to normal tissues.

Original languageEnglish (US)
Pages (from-to)385-392
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4257
DOIs
StatePublished - Jan 1 2001
EventLaser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical - San Jose, CA, United States
Duration: Jan 21 2001Jan 24 2001

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Keywords

  • Anti-cancer drug
  • Cavitation
  • Laser
  • Tumor
  • Ultrasound

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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