CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis

Windy Allman, Huibin Qi, Shamsher S. Saini, Jing Li, Erdem Tuzun, Premkumar Christadoss

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Neuroimmunology
Volume249
Issue number1-2
DOIs
StatePublished - Aug 15 2012

Keywords

  • Autoimmunity
  • CD4
  • Experimental autoimmune myasthenia gravis
  • Lipopolysaccharide
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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