CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis

Windy Allman; Huibin Qi; Shamsher S. Saini; Jing Li; Erdem Tuzun; Premkumar Christadoss

doi:10.1016/j.jneuroim.2012.04.002

CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis

Windy Allman
, Huibin Qi
, Shamsher S. Saini
, Jing Li
, Erdem Tuzun
, Premkumar Christadoss

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	249
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.04.002
State	Published - Aug 15 2012
Externally published	Yes

Keywords

Autoimmunity
CD4
Experimental autoimmune myasthenia gravis
Lipopolysaccharide
Myasthenia gravis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2012.04.002

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title = "CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis",

abstract = "The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle.",

keywords = "Autoimmunity, CD4, Experimental autoimmune myasthenia gravis, Lipopolysaccharide, Myasthenia gravis",

author = "Windy Allman and Huibin Qi and Saini, \{Shamsher S.\} and Jing Li and Erdem Tuzun and Premkumar Christadoss",

note = "Funding Information: This study is supported by MDA. Windy Allman is a recipient of a predoctoral fellowship from Association Franchaise contre les Myopathies. We thank S. Higgs and M.J. Susman for editing the manuscript. M. Griffin and W. Kaluarachchi for flow cytometry support and the UTMB Research Histopathology Core for sectioning and mounting tissues on to slides.",

year = "2012",

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day = "15",

doi = "10.1016/j.jneuroim.2012.04.002",

language = "English (US)",

volume = "249",

pages = "1--7",

journal = "Journal of Neuroimmunology",

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AU - Allman, Windy

AU - Qi, Huibin

AU - Saini, Shamsher S.

AU - Li, Jing

AU - Tuzun, Erdem

AU - Christadoss, Premkumar

N1 - Funding Information: This study is supported by MDA. Windy Allman is a recipient of a predoctoral fellowship from Association Franchaise contre les Myopathies. We thank S. Higgs and M.J. Susman for editing the manuscript. M. Griffin and W. Kaluarachchi for flow cytometry support and the UTMB Research Histopathology Core for sectioning and mounting tissues on to slides.

PY - 2012/8/15

Y1 - 2012/8/15

N2 - The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle.

AB - The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle.

KW - Autoimmunity

KW - CD4

KW - Experimental autoimmune myasthenia gravis

KW - Lipopolysaccharide

KW - Myasthenia gravis

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U2 - 10.1016/j.jneuroim.2012.04.002

DO - 10.1016/j.jneuroim.2012.04.002

M3 - Article

C2 - 22626443

AN - SCOPUS:84863463884

SN - 0165-5728

VL - 249

SP - 1

EP - 7

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis

Abstract

Keywords

ASJC Scopus subject areas

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