CD4+ T cell subsets and tax expression in HTLV-1 associated diseases

Nicolas Barros, Jorge Risco, Carlos Rodríguez, Cesar Sánchez, Elsa González, Yuetsu Tanaka, Eduardo Gotuzzo, A. Clinton White, Martin Montes

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalPathogens and Global Health
Volume107
Issue number4
DOIs
StatePublished - Jun 2013
Externally publishedYes

Fingerprint

Human T-lymphotropic virus 1
T-Lymphocyte Subsets
Strongyloides stercoralis
Spinal Cord Diseases
Lymphocytes
Tropical Spastic Paraparesis
Th1 Cells
Asymptomatic Infections
Viral Proteins
Virus Diseases
Regulatory T-Lymphocytes
Immunosuppressive Agents
Coinfection
Blood Cells
T-Lymphocytes

Keywords

  • Foxp3
  • HTLV-1
  • Immunology
  • Regulatory T cells
  • Tax
  • Th1

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Microbiology

Cite this

Barros, N., Risco, J., Rodríguez, C., Sánchez, C., González, E., Tanaka, Y., ... Montes, M. (2013). CD4+ T cell subsets and tax expression in HTLV-1 associated diseases. Pathogens and Global Health, 107(4), 202-206. https://doi.org/10.1179/2047773213Y.0000000091

CD4+ T cell subsets and tax expression in HTLV-1 associated diseases. / Barros, Nicolas; Risco, Jorge; Rodríguez, Carlos; Sánchez, Cesar; González, Elsa; Tanaka, Yuetsu; Gotuzzo, Eduardo; White, A. Clinton; Montes, Martin.

In: Pathogens and Global Health, Vol. 107, No. 4, 06.2013, p. 202-206.

Research output: Contribution to journalArticle

Barros, N, Risco, J, Rodríguez, C, Sánchez, C, González, E, Tanaka, Y, Gotuzzo, E, White, AC & Montes, M 2013, 'CD4+ T cell subsets and tax expression in HTLV-1 associated diseases', Pathogens and Global Health, vol. 107, no. 4, pp. 202-206. https://doi.org/10.1179/2047773213Y.0000000091
Barros N, Risco J, Rodríguez C, Sánchez C, González E, Tanaka Y et al. CD4+ T cell subsets and tax expression in HTLV-1 associated diseases. Pathogens and Global Health. 2013 Jun;107(4):202-206. https://doi.org/10.1179/2047773213Y.0000000091
Barros, Nicolas ; Risco, Jorge ; Rodríguez, Carlos ; Sánchez, Cesar ; González, Elsa ; Tanaka, Yuetsu ; Gotuzzo, Eduardo ; White, A. Clinton ; Montes, Martin. / CD4+ T cell subsets and tax expression in HTLV-1 associated diseases. In: Pathogens and Global Health. 2013 ; Vol. 107, No. 4. pp. 202-206.
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