Abstract
CD4+ T cells are components of the adaptive immune system that have a diverse repertoire of functions, which are defined by the production of specific cytokines and expression of distinct intracellular transcription factors and surface chemokine receptors. The functional diversity of T cells is demonstrated by the association of certain CD4+ T cell types (including Th1 CD4+ T cells) with positive cancer prognosis and other CD4+ T cell types (including T regulatory and Th2 CD4+ T cells) with a negative cancer prognosis. While the presence of CD4+ T cell subtypes correlates with tumor progression, the precise role of CD4+ T cells in such progression remains uncertain based on the indirect role that CD4+ T cells often play in helping or suppressing other immune cell types (including CD8+ T cells, dendritic cells, NK cells, and myeloid-derived suppressor cells). Clinical therapies focusing on generating anti-tumor CD4+ Tcell responses have been met with limited success. However, new approaches including Chimeric Antigen Receptors (CARs) may be increase the viability of CD4+ T cells as a potential therapeutic modality in the treatment of cancer.
Original language | English (US) |
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Title of host publication | Cancer Therapeutic Targets |
Publisher | Springer New York |
Pages | 117-129 |
Number of pages | 13 |
Volume | 1-2 |
ISBN (Electronic) | 9781441907172 |
ISBN (Print) | 9781441907165 |
DOIs | |
State | Published - Jan 1 2017 |
Externally published | Yes |
Keywords
- Adoptive transfer
- CD4+ T cells
- Clinical monitoring
- Evaluation
- Major histocompatibility complex II (MHC-II)
- Prognosis
- Regulatory T cells
- Subsets
- T cell receptor (TCR)
- T follicular helper (Tfh)
- T helper 1 (Th1) cells
- T helper 17 (Th17) cells
- T helper 2 (Th2) cells
- T helper 22 (Th22) cells
- T helper 9 (Th9) cells
- Therapy
- Tumor progression
- Types
- Unique aspect of
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology
- General Medicine