CD4+ T Cells

Frederick J. Kohlhapp, Andrew Zloza

Research output: Chapter in Book/Report/Conference proceedingChapter


CD4+ T cells are components of the adaptive immune system that have a diverse repertoire of functions, which are defined by the production of specific cytokines and expression of distinct intracellular transcription factors and surface chemokine receptors. The functional diversity of T cells is demonstrated by the association of certain CD4+ T cell types (including Th1 CD4+ T cells) with positive cancer prognosis and other CD4+ T cell types (including T regulatory and Th2 CD4+ T cells) with a negative cancer prognosis. While the presence of CD4+ T cell subtypes correlates with tumor progression, the precise role of CD4+ T cells in such progression remains uncertain based on the indirect role that CD4+ T cells often play in helping or suppressing other immune cell types (including CD8+ T cells, dendritic cells, NK cells, and myeloid-derived suppressor cells). Clinical therapies focusing on generating anti-tumor CD4+ Tcell responses have been met with limited success. However, new approaches including Chimeric Antigen Receptors (CARs) may be increase the viability of CD4+ T cells as a potential therapeutic modality in the treatment of cancer.

Original languageEnglish (US)
Title of host publicationCancer Therapeutic Targets
PublisherSpringer New York
Number of pages13
ISBN (Electronic)9781441907172
ISBN (Print)9781441907165
StatePublished - Jan 1 2017
Externally publishedYes


  • Adoptive transfer
  • CD4+ T cells
  • Clinical monitoring
  • Evaluation
  • Major histocompatibility complex II (MHC-II)
  • Prognosis
  • Regulatory T cells
  • Subsets
  • T cell receptor (TCR)
  • T follicular helper (Tfh)
  • T helper 1 (Th1) cells
  • T helper 17 (Th17) cells
  • T helper 2 (Th2) cells
  • T helper 22 (Th22) cells
  • T helper 9 (Th9) cells
  • Therapy
  • Tumor progression
  • Types
  • Unique aspect of

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


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