CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus

Nadezhda E. Yun, Bihung Peng, Andrea S. Bertke, Viktoriya Borisevich, Jennifer K. Smith, Jeanon N. Smith, Allison L. Poussard, Milagros Salazar, Barbara M. Judy, Michele A. Zacks, D. Mark Estes, Slobodan Paessler

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Studying the mechanisms of host survival resulting from viral encephalitis is critical to the development of vaccines. Here we have shown in several independent studies that high dose treatment with neutralizing antibody prior to intranasal infection with Venezuelan equine encephalitis virus had an antiviral effect in the visceral organs and prolonged survival time of infected mice, even in the absence of αβ T cells. Nevertheless, antibody treatment did not prevent the development of lethal encephalitis. On the contrary, the adoptive transfer of primed CD4+ T cells was necessary to prevent lethal encephalitis in mice lacking αβ T cell receptor.

Original languageEnglish (US)
Pages (from-to)4064-4073
Number of pages10
JournalVaccine
Volume27
Issue number30
DOIs
StatePublished - Jun 19 2009

Fingerprint

Venezuelan Equine Encephalitis Viruses
Venezuelan equine encephalitis virus
Cytoprotection
Encephalitis
encephalitis
T-lymphocytes
Viral Encephalitis
T-Lymphocytes
Tissue Survival
Adoptive Transfer
T-Cell Antigen Receptor
Neutralizing Antibodies
viral encephalitis
Antiviral Agents
Vaccines
mice
vaccine development
neutralizing antibodies
Antibodies
Therapeutics

Keywords

  • Animal models
  • Vaccine
  • Venezuelan equine encephalitis virus

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus. / Yun, Nadezhda E.; Peng, Bihung; Bertke, Andrea S.; Borisevich, Viktoriya; Smith, Jennifer K.; Smith, Jeanon N.; Poussard, Allison L.; Salazar, Milagros; Judy, Barbara M.; Zacks, Michele A.; Estes, D. Mark; Paessler, Slobodan.

In: Vaccine, Vol. 27, No. 30, 19.06.2009, p. 4064-4073.

Research output: Contribution to journalArticle

Yun, NE, Peng, B, Bertke, AS, Borisevich, V, Smith, JK, Smith, JN, Poussard, AL, Salazar, M, Judy, BM, Zacks, MA, Estes, DM & Paessler, S 2009, 'CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus', Vaccine, vol. 27, no. 30, pp. 4064-4073. https://doi.org/10.1016/j.vaccine.2009.04.015
Yun, Nadezhda E. ; Peng, Bihung ; Bertke, Andrea S. ; Borisevich, Viktoriya ; Smith, Jennifer K. ; Smith, Jeanon N. ; Poussard, Allison L. ; Salazar, Milagros ; Judy, Barbara M. ; Zacks, Michele A. ; Estes, D. Mark ; Paessler, Slobodan. / CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus. In: Vaccine. 2009 ; Vol. 27, No. 30. pp. 4064-4073.
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