CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus

Nadezhda E. Yun, Bi Hung Peng, Andrea S. Bertke, Viktoriya Borisevich, Jennifer K. Smith, Jeanon N. Smith, Allison L. Poussard, Milagros Salazar, Barbara M. Judy, Michele A. Zacks, D. Mark Estes, Slobodan Paessler

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Studying the mechanisms of host survival resulting from viral encephalitis is critical to the development of vaccines. Here we have shown in several independent studies that high dose treatment with neutralizing antibody prior to intranasal infection with Venezuelan equine encephalitis virus had an antiviral effect in the visceral organs and prolonged survival time of infected mice, even in the absence of αβ T cells. Nevertheless, antibody treatment did not prevent the development of lethal encephalitis. On the contrary, the adoptive transfer of primed CD4+ T cells was necessary to prevent lethal encephalitis in mice lacking αβ T cell receptor.

Original languageEnglish (US)
Pages (from-to)4064-4073
Number of pages10
JournalVaccine
Volume27
Issue number30
DOIs
StatePublished - Jun 19 2009

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Keywords

  • Animal models
  • Vaccine
  • Venezuelan equine encephalitis virus

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Yun, N. E., Peng, B. H., Bertke, A. S., Borisevich, V., Smith, J. K., Smith, J. N., Poussard, A. L., Salazar, M., Judy, B. M., Zacks, M. A., Estes, D. M., & Paessler, S. (2009). CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus. Vaccine, 27(30), 4064-4073. https://doi.org/10.1016/j.vaccine.2009.04.015