Cd4+lymphocytes in perinatal human immunodeficiency virus (hiv) infection: Evidence for pregnancy-induced immune depressionin uninfected and hiv-infeeted women

Kenneth C. Rich, Joan N. Siegel, Cheryl Jennings, Robert J. Rydman, Alan L. Landay

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Immune function changes during pregnancy and human immunodeficiency virus (HIV) infection. T helper function and phenotypes in HIV-infected and -uninfected pregnant and postpartum women and nonpregnant uninfected control women were studied. T helper function was assessed by interleukin- 2 (IL-2) production in vitro and three-color flow cytometry. All uninfected nonpregnant subjects, 74% of uninfected pregnant subjects, and only 54% of HIV-infected pregnant subjects responded to all stimuli. All uninfected subjects 2-6 months postpartum had normal function versus 27% of infected subjects (trend P <.001). Uninfected pregnant subjects had reduced levels of CD4+CD45RARO+(memory) and elevated levels of CD4+CD45RA+RO(naive) lymphocytes. Infected pregnant subjects had elevated levels of memory, reduced levels of naive, and increased levels of CD4+HLA-DR+CD38+(activated) lymphocytes. Increased CD4+DR+CD38+cells correlated best with poor IL-2 function, HIV infection, and being postpartum (R2=.79). Thus, T helper function and phenotypes are altered in pregnancy and return to baseline postpartum in uninfected but not HIV-infected women.

Original languageEnglish (US)
Pages (from-to)1221-1227
Number of pages7
JournalJournal of Infectious Diseases
Volume172
Issue number5
DOIs
StatePublished - Nov 1995
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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