CD4+T cell metabolism, gut microbiota, and autoimmune diseases: Implication in precision medicine of autoimmune diseases

Wenjing Yang, Tianming Yu, Yingzi Cong

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

CD4+ T cells are critical to the development of autoimmune disorders. Glucose, fatty acids, and glutamine metabolisms are the primary metabolic pathways in immune cells, including CD4+ T cells. The distinct metabolic programs in CD4+ T cell subsets are recognized to reflect the bioenergetic requirements, which are compatible with their functional demands. Gut microbiota affects T cell responses by providing a series of antigens and metabolites. Accumulating data indicate that CD4+ T cell metabolic pathways underlie aberrant T cell functions, thereby regulating the pathogenesis of autoimmune disorders, including inflammatory bowel diseases, systemic lupus erythematosus, and rheumatoid arthritis. Here, we summarize the current progress of CD4+ T cell metabolic programs, gut microbiota regulation of T cell metabolism, and T cell metabolic adaptions to autoimmune disorders to shed light on potential metabolic therapeutics for autoimmune diseases.

Original languageEnglish (US)
Article numberpbac018
JournalPrecision Clinical Medicine
Volume5
Issue number3
DOIs
StatePublished - Aug 2022

Keywords

  • autoimmune disorders
  • gut microbiota
  • immunometabolism
  • metabolic adaption

ASJC Scopus subject areas

  • General Medicine

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