CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

Ellen J. Beswick, Victor E. Reyes

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)2855-2861
Number of pages7
JournalWorld journal of gastroenterology
Volume15
Issue number23
DOIs
StatePublished - Jun 21 2009

Keywords

  • CD74
  • Cancer
  • Gastrointestinal tract
  • Helicobacter pylori
  • Inflammation
  • Invariant chain

ASJC Scopus subject areas

  • Gastroenterology

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