Cell activation signals and the pathogenesis of human cytomegalovirus

T. Albrecht, Istvan Boldogh, M. Fons, S. AbuBakar, C. Z. Deng

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) infection induces a series of cellular responses that resemble those observed in cells activated by growth factors or hormones including: hydrolysis of phosphatidylinositol-4,5-bisphosphate; Ca2+ influx and an inrease in the cytosolic free [Ca2+]; an increase in Na+ entry; and, increases in cellular levels of cyclic AMP and cyclic GMP. The time courses for some of these responses appear to be markedly protracted relative to those observed for growth factors. The prolonged physiologic responses in CMV-infected cells appear to be related to modifications in the intracellular environment that are associated with the development of cytomegaly and with the phasing of CMV-directed macromolecular synthesis. For example, as the infected cell enlarges, the rate of CMV DNA synthesis increases by about 4-fold, late nuclear inclusions develop and progeny viruses are formed. When the CMV-induced activation signals are inhibited or their physiologic responses are blocked, then the yields of infectious CMV are substantially reduced. Furthermore, perturbation of the cell cycle resulting from induction of cell activation process by CMV may be causally related to the induction of cellular damage by CMV, even in the absence of productive infection. Accordingly, the CMV-induced pathophysiologic cell activation responses represent potential targets for novel antiviral therapy.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalIntervirology
Volume31
Issue number2-4
StatePublished - 1990

Fingerprint

Cytomegalovirus
Intercellular Signaling Peptides and Proteins
Intranuclear Inclusion Bodies
Cyclic GMP
Cytomegalovirus Infections
Phosphatidylinositols
Cyclic AMP
Growth Hormone
Antiviral Agents
Cell Cycle
Hydrolysis
Viruses
DNA
Infection

Keywords

  • Amiloride
  • Ca
  • cAMP
  • Cell activation
  • cGMP
  • Cytomegalovirus
  • Inositol phospholipids
  • Papaverine

ASJC Scopus subject areas

  • Virology

Cite this

Albrecht, T., Boldogh, I., Fons, M., AbuBakar, S., & Deng, C. Z. (1990). Cell activation signals and the pathogenesis of human cytomegalovirus. Intervirology, 31(2-4), 68-75.

Cell activation signals and the pathogenesis of human cytomegalovirus. / Albrecht, T.; Boldogh, Istvan; Fons, M.; AbuBakar, S.; Deng, C. Z.

In: Intervirology, Vol. 31, No. 2-4, 1990, p. 68-75.

Research output: Contribution to journalArticle

Albrecht, T, Boldogh, I, Fons, M, AbuBakar, S & Deng, CZ 1990, 'Cell activation signals and the pathogenesis of human cytomegalovirus', Intervirology, vol. 31, no. 2-4, pp. 68-75.
Albrecht T, Boldogh I, Fons M, AbuBakar S, Deng CZ. Cell activation signals and the pathogenesis of human cytomegalovirus. Intervirology. 1990;31(2-4):68-75.
Albrecht, T. ; Boldogh, Istvan ; Fons, M. ; AbuBakar, S. ; Deng, C. Z. / Cell activation signals and the pathogenesis of human cytomegalovirus. In: Intervirology. 1990 ; Vol. 31, No. 2-4. pp. 68-75.
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