Cell biology: Logic of the yeast metabolic cycle: Temporal compartmentalization of cellular processes

Benjamin P. Tu, Andrzej Kudlicki, Maga Rowicka, Steven L. McKnight

Research output: Contribution to journalArticle

602 Scopus citations

Abstract

Budding yeast grown under continuous, nutrient-limited conditions exhibit robust, highly periodic cycles in the form of respiratory bursts. Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles. Genes encoding proteins having a common function exhibit similar temporal expression patterns, and genes specifying functions associated with energy and metabolism tend to be expressed with exceptionally robust periodicity. Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time.

Original languageEnglish (US)
Pages (from-to)1152-1158
Number of pages7
JournalScience
Volume310
Issue number5751
DOIs
StatePublished - Nov 18 2005

ASJC Scopus subject areas

  • General

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