Cell biology: Logic of the yeast metabolic cycle: Temporal compartmentalization of cellular processes

Benjamin P. Tu, Andrzej Kudlicki, Malgorzata Rowicka-Kudlicka, Steven L. McKnight

Research output: Contribution to journalArticle

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Budding yeast grown under continuous, nutrient-limited conditions exhibit robust, highly periodic cycles in the form of respiratory bursts. Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles. Genes encoding proteins having a common function exhibit similar temporal expression patterns, and genes specifying functions associated with energy and metabolism tend to be expressed with exceptionally robust periodicity. Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time.

Original languageEnglish (US)
Pages (from-to)1152-1158
Number of pages7
Issue number5751
StatePublished - Nov 18 2005
Externally publishedYes


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