Abstract
This chapter provides an overview of cell culture models that may be used to predict drug transport across relevant biological barriers. General considerations regarding the utility of such a model are discussed, followed by a brief description of physiological cell barrier properties and cell culture models that have been utilized or proposed to understand mechanisms of drug transport in the intestinal epithelium, the blood-brain barrier (BBB), nasal and pulmonary epithelium, ocular epithelial and endothelial barriers, the placenta, and renal epithelium. To date, a number of in vitro models of the intestinal epithelium have been investigated, all of which may possess different characteristics and, thus, have different potential applications in the study of drug transport. The chapter introduces primary cell models, and discusses some of the advantages and limitations of certain cell line models.
Original language | English (US) |
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Title of host publication | Drug Delivery: Principles and Applications: Second Edition |
Publisher | wiley |
Pages | 131-151 |
Number of pages | 21 |
ISBN (Electronic) | 9781118833322 |
ISBN (Print) | 9781118833360 |
DOIs | |
State | Published - Mar 25 2016 |
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Keywords
- Blood-brain barrier
- Cell culture models
- Drug transport
- Intestinal epithelium
- Pulmonary epithelium
- Renal epithelium
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
- Engineering(all)
- Medicine(all)
Cite this
Cell Culture Models for Drug Transport Studies. / Kalashnikova, Irina; Albekairi, Norah; Ali, Shariq; Al Enazy, Sanaalarab; Rytting, Erik.
Drug Delivery: Principles and Applications: Second Edition. wiley, 2016. p. 131-151.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Cell Culture Models for Drug Transport Studies
AU - Kalashnikova, Irina
AU - Albekairi, Norah
AU - Ali, Shariq
AU - Al Enazy, Sanaalarab
AU - Rytting, Erik
PY - 2016/3/25
Y1 - 2016/3/25
N2 - This chapter provides an overview of cell culture models that may be used to predict drug transport across relevant biological barriers. General considerations regarding the utility of such a model are discussed, followed by a brief description of physiological cell barrier properties and cell culture models that have been utilized or proposed to understand mechanisms of drug transport in the intestinal epithelium, the blood-brain barrier (BBB), nasal and pulmonary epithelium, ocular epithelial and endothelial barriers, the placenta, and renal epithelium. To date, a number of in vitro models of the intestinal epithelium have been investigated, all of which may possess different characteristics and, thus, have different potential applications in the study of drug transport. The chapter introduces primary cell models, and discusses some of the advantages and limitations of certain cell line models.
AB - This chapter provides an overview of cell culture models that may be used to predict drug transport across relevant biological barriers. General considerations regarding the utility of such a model are discussed, followed by a brief description of physiological cell barrier properties and cell culture models that have been utilized or proposed to understand mechanisms of drug transport in the intestinal epithelium, the blood-brain barrier (BBB), nasal and pulmonary epithelium, ocular epithelial and endothelial barriers, the placenta, and renal epithelium. To date, a number of in vitro models of the intestinal epithelium have been investigated, all of which may possess different characteristics and, thus, have different potential applications in the study of drug transport. The chapter introduces primary cell models, and discusses some of the advantages and limitations of certain cell line models.
KW - Blood-brain barrier
KW - Cell culture models
KW - Drug transport
KW - Intestinal epithelium
KW - Pulmonary epithelium
KW - Renal epithelium
UR - http://www.scopus.com/inward/record.url?scp=85017395317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017395317&partnerID=8YFLogxK
U2 - 10.1002/9781118833322.ch7
DO - 10.1002/9781118833322.ch7
M3 - Chapter
AN - SCOPUS:85017395317
SN - 9781118833360
SP - 131
EP - 151
BT - Drug Delivery: Principles and Applications: Second Edition
PB - wiley
ER -