Abstract
This chapter provides an overview of cell culture models that may be used to predict drug transport across relevant biological barriers. General considerations regarding the utility of such a model are discussed, followed by a brief description of physiological cell barrier properties and cell culture models that have been utilized or proposed to understand mechanisms of drug transport in the intestinal epithelium, the blood-brain barrier (BBB), nasal and pulmonary epithelium, ocular epithelial and endothelial barriers, the placenta, and renal epithelium. To date, a number of in vitro models of the intestinal epithelium have been investigated, all of which may possess different characteristics and, thus, have different potential applications in the study of drug transport. The chapter introduces primary cell models, and discusses some of the advantages and limitations of certain cell line models.
Original language | English (US) |
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Title of host publication | Drug Delivery |
Subtitle of host publication | Principles and Applications: Second Edition |
Publisher | wiley |
Pages | 131-151 |
Number of pages | 21 |
ISBN (Electronic) | 9781118833322 |
ISBN (Print) | 9781118833360 |
DOIs | |
State | Published - Mar 25 2016 |
Keywords
- Blood-brain barrier
- Cell culture models
- Drug transport
- Intestinal epithelium
- Pulmonary epithelium
- Renal epithelium
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering
- General Engineering
- General Medicine