Cell Culture Models for Drug Transport Studies

Irina Kalashnikova, Norah Albekairi, Shariq Ali, Sanaalarab Al Enazy, Erik Rytting

    Research output: Chapter in Book/Report/Conference proceedingChapter

    3 Scopus citations

    Abstract

    This chapter provides an overview of cell culture models that may be used to predict drug transport across relevant biological barriers. General considerations regarding the utility of such a model are discussed, followed by a brief description of physiological cell barrier properties and cell culture models that have been utilized or proposed to understand mechanisms of drug transport in the intestinal epithelium, the blood-brain barrier (BBB), nasal and pulmonary epithelium, ocular epithelial and endothelial barriers, the placenta, and renal epithelium. To date, a number of in vitro models of the intestinal epithelium have been investigated, all of which may possess different characteristics and, thus, have different potential applications in the study of drug transport. The chapter introduces primary cell models, and discusses some of the advantages and limitations of certain cell line models.

    Original languageEnglish (US)
    Title of host publicationDrug Delivery: Principles and Applications: Second Edition
    Publisherwiley
    Pages131-151
    Number of pages21
    ISBN (Electronic)9781118833322
    ISBN (Print)9781118833360
    DOIs
    StatePublished - Mar 25 2016

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    Keywords

    • Blood-brain barrier
    • Cell culture models
    • Drug transport
    • Intestinal epithelium
    • Pulmonary epithelium
    • Renal epithelium

    ASJC Scopus subject areas

    • Chemistry(all)
    • Chemical Engineering(all)
    • Engineering(all)
    • Medicine(all)

    Cite this

    Kalashnikova, I., Albekairi, N., Ali, S., Al Enazy, S., & Rytting, E. (2016). Cell Culture Models for Drug Transport Studies. In Drug Delivery: Principles and Applications: Second Edition (pp. 131-151). wiley. https://doi.org/10.1002/9781118833322.ch7