Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways

Viola Vogel, Michael Sheetz

Research output: Contribution to journalReview article

198 Citations (Scopus)

Abstract

Many aspects of cellular motility and mechanics are cyclic in nature such as the extension and retraction of lamellipodia or filopodia. Inherent to the cycles of extension and retraction that test the environment is the production of mechano-chemical signals that can alter long-term cell behavior, transcription patterns, and cell fate. We are just starting to define such cycles in several aspects of cell motility, including periodic contractions, integrin cycles of binding and release as well as the normal oscillations in motile activity. Cycles of local cell contraction and release are directly coupled to cycles of stressing and releasing extracellular contacts (matrix or cells) as well as cytoplasmic mechanotransducers. Stretching can alter external physical properties or sites exposed by matrix molecules as well as internal networks; thus, cell contractions can cause a secondary wave of mechano-regulated outside-in and internal cell signal changes. In some cases, the integration of both external and internal signals in space and time can stimulate a change in cell state from quiescence to growth or differentiation. In this review we will develop the basic concept of the mechano-chemical cycles and the ways in which they can be described and understood.

Original languageEnglish (US)
Pages (from-to)38-46
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2009
Externally publishedYes

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Pseudopodia
Chemical Phenomena
Mechanics
Integrins
Cell Movement
Extracellular Matrix
Cell Cycle
Growth

ASJC Scopus subject areas

  • Cell Biology

Cite this

Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways. / Vogel, Viola; Sheetz, Michael.

In: Current Opinion in Cell Biology, Vol. 21, No. 1, 01.02.2009, p. 38-46.

Research output: Contribution to journalReview article

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