TY - JOUR
T1 - Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60
AU - Wayne, S. J.
AU - Rhyne, R. L.
AU - Garry, P. J.
AU - Goodwin, J. S.
PY - 1990
Y1 - 1990
N2 - Previous studies have suggested an association between depressed cell-mediated immunity and increased mortality in elderly persons. However, the effects of age and existing disease on this association have not been adequately addressed. We studied the association between cell-mediated immunity and subsequent morbidity and mortality in 273 initially healthy persons 60 years of age and older. In 1979, two tests of cell-mediated immunity were conducted - mitogen stimulation with phytohaemagglutinin, and delayed hypersensitivity skin testing. The study group was followed annually for development of pneumonia, cancer, and death. Anergy was associated with all-cause mortality (hazard ratio of 2.16; 95% confidence interval [1.10,4.28]). When the results were adjusted for age, the resulting hazard ratio was 1.89;[0.94,3.79]. A relationship was also suggested between anergy and cancer mortality although this association was not statistically significant. Response to phytohaemagglutinin was a poorer predictor of mortality than was response to delayed hypersensitivity skin testing. The results show that anergy may be a good indicator of subsequent all-cause morbidity, and perhaps cancer mortality, in elderly who lack other indicators of poor health.
AB - Previous studies have suggested an association between depressed cell-mediated immunity and increased mortality in elderly persons. However, the effects of age and existing disease on this association have not been adequately addressed. We studied the association between cell-mediated immunity and subsequent morbidity and mortality in 273 initially healthy persons 60 years of age and older. In 1979, two tests of cell-mediated immunity were conducted - mitogen stimulation with phytohaemagglutinin, and delayed hypersensitivity skin testing. The study group was followed annually for development of pneumonia, cancer, and death. Anergy was associated with all-cause mortality (hazard ratio of 2.16; 95% confidence interval [1.10,4.28]). When the results were adjusted for age, the resulting hazard ratio was 1.89;[0.94,3.79]. A relationship was also suggested between anergy and cancer mortality although this association was not statistically significant. Response to phytohaemagglutinin was a poorer predictor of mortality than was response to delayed hypersensitivity skin testing. The results show that anergy may be a good indicator of subsequent all-cause morbidity, and perhaps cancer mortality, in elderly who lack other indicators of poor health.
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U2 - 10.1093/geronj/45.2.M45
DO - 10.1093/geronj/45.2.M45
M3 - Article
C2 - 2313042
AN - SCOPUS:0025213974
SN - 0022-1422
VL - 45
SP - M45-M48
JO - Journal of Gerontology: Social Sciences
JF - Journal of Gerontology: Social Sciences
IS - 2
ER -