Abstract
Cell migration relies upon forces generated by the cell. Recent studies have provided new insights into the processes by which cells generate and regulate the forces applied to extracellular matrix (ECM)-bound integrins and have led us to the working model described here. In this model, ECM binding to integrins in the front of lamellipodia causes those integrins to attach to the rearward-moving cytoskeleton. Integrin-cytoskeleton attatchments in the front are strengthened as a result of ECM rigidity, enabling the cell to pull itself forward. The reduction in contact area at the rear compared with that at the lamellipodium concentrates the traction forces in the rear on fewer integrin-ECM bonds, facilitating release. In such a model, cell pathfinding and motility can be influenced by ECM rigidity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 51-54 |
| Number of pages | 4 |
| Journal | Trends in Cell Biology |
| Volume | 8 |
| Issue number | 2 |
| DOIs |
|
| State | Published - Jan 1 1998 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Cell migration : Regulation of force on extracellular-matrix-integrin complexes. / Sheetz, Michael; Felsenfeld, Dan P.; Galbraith, Catherine G.
In: Trends in Cell Biology, Vol. 8, No. 2, 01.01.1998, p. 51-54.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - Cell migration
T2 - Regulation of force on extracellular-matrix-integrin complexes
AU - Sheetz, Michael
AU - Felsenfeld, Dan P.
AU - Galbraith, Catherine G.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Cell migration relies upon forces generated by the cell. Recent studies have provided new insights into the processes by which cells generate and regulate the forces applied to extracellular matrix (ECM)-bound integrins and have led us to the working model described here. In this model, ECM binding to integrins in the front of lamellipodia causes those integrins to attach to the rearward-moving cytoskeleton. Integrin-cytoskeleton attatchments in the front are strengthened as a result of ECM rigidity, enabling the cell to pull itself forward. The reduction in contact area at the rear compared with that at the lamellipodium concentrates the traction forces in the rear on fewer integrin-ECM bonds, facilitating release. In such a model, cell pathfinding and motility can be influenced by ECM rigidity.
AB - Cell migration relies upon forces generated by the cell. Recent studies have provided new insights into the processes by which cells generate and regulate the forces applied to extracellular matrix (ECM)-bound integrins and have led us to the working model described here. In this model, ECM binding to integrins in the front of lamellipodia causes those integrins to attach to the rearward-moving cytoskeleton. Integrin-cytoskeleton attatchments in the front are strengthened as a result of ECM rigidity, enabling the cell to pull itself forward. The reduction in contact area at the rear compared with that at the lamellipodium concentrates the traction forces in the rear on fewer integrin-ECM bonds, facilitating release. In such a model, cell pathfinding and motility can be influenced by ECM rigidity.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031964022&partnerID=8YFLogxK
U2 - 10.1016/S0962-8924(98)80005-6
DO - 10.1016/S0962-8924(98)80005-6
M3 - Comment/debate
VL - 8
SP - 51
EP - 54
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 2
ER -