Cells of origin of the spinoreticular tract in the monkey

G. A. Kevetter, L. H. Haber, R. P. Yezierski, Jin Chung, R. F. Martin, W. D. Willis

Research output: Contribution to journalArticle

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Abstract

The distribution of the cells of origin of the primate spinoreticular tract was determined following injections of horseradish peroxidase (HRP) into the pontomedullary reticular formation in Macaca fascicularis. Five animals received large bilateral injections which included the raphe nuclei and seven monkeys received smaller, unilateral injections. Sections sampled were from upper cervical levels, the cervical enlargement, upper and lower thoracic levels, and lumbosacral levels. The laminar distribution of spinoreticular cells in all spinal cord levels was comparable. More than half of the labeled cells were located ventromedially, in laminae VII and VIII. HRP-labeled cells were also found in the dorsal horn, primarily in the lateral reticulated part of laminae V. Some cells were also found in laminae I and X. Spinoreticular cells in the lumbosacral spinal cord mainly projected to the contralateral brainstem. In the cervical enlargement, however, a bilateral distribution of cells was observed following unilateral injections of HRP. Most spinoreticular cells were multipolar neurons with extensive dendritic ramifications. The distribution of spinoreticular cells is similar to the distribution of spinal cord neurons that project to the medial thalamus, but different from that of spinal neurons projecting to the ventrobasal complex. The anatomical organization of the spinoreticular tract is consistent with a role for this pathway in nociception.

Original languageEnglish (US)
Pages (from-to)61-74
Number of pages14
JournalJournal of Comparative Neurology
Volume207
Issue number1
DOIs
StatePublished - 1982

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Haplorhini
Horseradish Peroxidase
Spinal Cord
Injections
Neurons
Ventral Thalamic Nuclei
Raphe Nuclei
Reticular Formation
Nociception
Macaca fascicularis
Thalamus
Primates
Brain Stem
Thorax

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kevetter, G. A., Haber, L. H., Yezierski, R. P., Chung, J., Martin, R. F., & Willis, W. D. (1982). Cells of origin of the spinoreticular tract in the monkey. Journal of Comparative Neurology, 207(1), 61-74. https://doi.org/10.1002/cne.902070106

Cells of origin of the spinoreticular tract in the monkey. / Kevetter, G. A.; Haber, L. H.; Yezierski, R. P.; Chung, Jin; Martin, R. F.; Willis, W. D.

In: Journal of Comparative Neurology, Vol. 207, No. 1, 1982, p. 61-74.

Research output: Contribution to journalArticle

Kevetter, GA, Haber, LH, Yezierski, RP, Chung, J, Martin, RF & Willis, WD 1982, 'Cells of origin of the spinoreticular tract in the monkey', Journal of Comparative Neurology, vol. 207, no. 1, pp. 61-74. https://doi.org/10.1002/cne.902070106
Kevetter, G. A. ; Haber, L. H. ; Yezierski, R. P. ; Chung, Jin ; Martin, R. F. ; Willis, W. D. / Cells of origin of the spinoreticular tract in the monkey. In: Journal of Comparative Neurology. 1982 ; Vol. 207, No. 1. pp. 61-74.
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