CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS

Kent J. Weinhold, Thomas J. Matthews, Paul M. Ahearne, Alphonse J. Langlois, H. Kim Lyerly, Douglas S. Tyler, Kimo C. Stine, David T. Durack, Dani P. Bolognesi

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Abstract

Forty-one patients seropositive for human immunodeficiency virus type 1 (HIV-1) were assessed for cell-mediated cytotoxicity (CMC) against autologous target cells bearing the major envelope glycoprotein of HIV-1, gp120. Effector lymphocytes from over 85% of seropositive patients showed CMC specific for gp120-coated targets, whereas seronegative individuals had no detectable CMC. As a group, symptomless individuals had the highest levels of CMC; patients with AIDS-related complex and AIDS showed progressively diminished reactivity. The gp120-specific CMC was mediated by a population of non-T-cell effectors phenotypically resembling NK/K cells. Cytolysis was not restricted by major histocompatibility complex determinants, as shown by killing of heterologous gp120-adsorbed targets and of HIV-1-infected cell-lines. Gp120-specific CMC was highly augmented in the presence of interleukin 2, so it may be possible to develop therapeutic strategies aimed at destruction of virus-producing cell reservoirs in infected individuals through stimulation of HIV-specific host CMC.

Original languageEnglish (US)
Pages (from-to)902-905
Number of pages4
JournalThe Lancet
Volume331
Issue number8591
DOIs
StatePublished - Apr 23 1988

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Weinhold, K. J., Matthews, T. J., Ahearne, P. M., Langlois, A. J., Lyerly, H. K., Tyler, D. S., Stine, K. C., Durack, D. T., & Bolognesi, D. P. (1988). CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS. The Lancet, 331(8591), 902-905. https://doi.org/10.1016/S0140-6736(88)91713-8