CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS

KentJ Weinhold, ThomasJ Matthews, PaulM Ahearne, AlphonseJ Langlois, H. Kim Lyerly, Douglas Tyler, KimoC Stine, DavidT Durack, DaniP Bolognesi

Research output: Contribution to journalArticle

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Abstract

Forty-one patients seropositive for human immunodeficiency virus type 1 (HIV-1) were assessed for cell-mediated cytotoxicity (CMC) against autologous target cells bearing the major envelope glycoprotein of HIV-1, gp120. Effector lymphocytes from over 85% of seropositive patients showed CMC specific for gp120-coated targets, whereas seronegative individuals had no detectable CMC. As a group, symptomless individuals had the highest levels of CMC; patients with AIDS-related complex and AIDS showed progressively diminished reactivity. The gp120-specific CMC was mediated by a population of non-T-cell effectors phenotypically resembling NK/K cells. Cytolysis was not restricted by major histocompatibility complex determinants, as shown by killing of heterologous gp120-adsorbed targets and of HIV-1-infected cell-lines. Gp120-specific CMC was highly augmented in the presence of interleukin 2, so it may be possible to develop therapeutic strategies aimed at destruction of virus-producing cell reservoirs in infected individuals through stimulation of HIV-specific host CMC.

Original languageEnglish (US)
Pages (from-to)902-905
Number of pages4
JournalThe Lancet
Volume331
Issue number8591
DOIs
StatePublished - Apr 23 1988
Externally publishedYes

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HIV-1
AIDS-Related Complex
Major Histocompatibility Complex
Natural Killer Cells
Interleukin-2
Glycoproteins
Acquired Immunodeficiency Syndrome
HIV
Lymphocytes
Viruses
Cell Line
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Weinhold, K., Matthews, T., Ahearne, P., Langlois, A., Lyerly, H. K., Tyler, D., ... Bolognesi, D. (1988). CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS. The Lancet, 331(8591), 902-905. https://doi.org/10.1016/S0140-6736(88)91713-8

CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS. / Weinhold, KentJ; Matthews, ThomasJ; Ahearne, PaulM; Langlois, AlphonseJ; Lyerly, H. Kim; Tyler, Douglas; Stine, KimoC; Durack, DavidT; Bolognesi, DaniP.

In: The Lancet, Vol. 331, No. 8591, 23.04.1988, p. 902-905.

Research output: Contribution to journalArticle

Weinhold, K, Matthews, T, Ahearne, P, Langlois, A, Lyerly, HK, Tyler, D, Stine, K, Durack, D & Bolognesi, D 1988, 'CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS', The Lancet, vol. 331, no. 8591, pp. 902-905. https://doi.org/10.1016/S0140-6736(88)91713-8
Weinhold K, Matthews T, Ahearne P, Langlois A, Lyerly HK, Tyler D et al. CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS. The Lancet. 1988 Apr 23;331(8591):902-905. https://doi.org/10.1016/S0140-6736(88)91713-8
Weinhold, KentJ ; Matthews, ThomasJ ; Ahearne, PaulM ; Langlois, AlphonseJ ; Lyerly, H. Kim ; Tyler, Douglas ; Stine, KimoC ; Durack, DavidT ; Bolognesi, DaniP. / CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS. In: The Lancet. 1988 ; Vol. 331, No. 8591. pp. 902-905.
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