Cellular behavior change of macrophage after exposure to nanoparticles

J. K. Hsiao, T. I. Weng, M. F. Tai, Y. F. Chen, Y. H. Wang, C. Y. Yang, J. L. Wang, H. M. Liu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Magnetic nanoparticles (MNPs) are few of the nanoparticles used clinically. When MNPs are delivered into human body, they are ingested by macrophages. We evaluated the cellular response of macrophage after MNPs loading. In face of stimulation by lipopolysaccharide, a strong stimulant derived from bacterial cell wall, MNPs loaded macrophage exhibited decreased phagocytic activity and decreased generation of cytokines such as TNF-a, IL-1J3 whereas increased nitric oxide generation was noticed. Although these changes might decrease bactiericidal activity, it also alleviates the risk of senses, a life threatening phenomenon in infection patients. The finding has significant implications on nanoparticle based targeted drug delivery.

Original languageEnglish (US)
Pages (from-to)1388-1393
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Issue number2
StatePublished - Feb 1 2009
Externally publishedYes


  • Macrophage
  • Magnetic nanoparticles
  • Magnetic resonance imaging.

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics


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