Cellular immunity in Q fever

Specific lymphocyte unresponsiveness in Q fever endocarditis

F. T. Koster, J. C. Williams, James Goodwin

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Human infection with the rickettsia Coxiella burnetii presents as actue influenza-like primary Q fever, subacute granulomatous hepatitis, or chronic endocarditis with hepatitis. To investigate whether persistent infection is associated with a possible immunologic defect, we tested lymphocyte proliferation specific for Coxiella in vitro in peripheral blood mononuclear cells from patients and controls. All four patients with endocarditis had profound lymphocyte unresponsiveness to Coxiella antigens with normal proliferation to control antigens. Hepatitis and primary Q fever were associated with vigorous responses in vitro to Coxiella antigens. Suppression of lymphocyte unresponsiveness was in part mediated by an antigen-nonspecific, glass-adherent cell. We hypothesize that specific T cell unresponsiveness is an important factor in persistent infection with C. burnetii and offer in vitro lymphocyte stimulation as a more specific diagnostic test to distinguish cases of endocarditis among those with chronic hepatitis due to Q fever.

Original languageEnglish (US)
Pages (from-to)1283-1289
Number of pages7
JournalJournal of Infectious Diseases
Volume152
Issue number6
StatePublished - 1985
Externally publishedYes

Fingerprint

Q Fever
Coxiella
Endocarditis
Cellular Immunity
Lymphocytes
Antigens
Chronic Hepatitis
Hepatitis
Rickettsia Infections
Coxiella burnetii
Lymphocyte Activation
Routine Diagnostic Tests
Human Influenza
Glass
Blood Cells
T-Lymphocytes
Infection
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Cellular immunity in Q fever : Specific lymphocyte unresponsiveness in Q fever endocarditis. / Koster, F. T.; Williams, J. C.; Goodwin, James.

In: Journal of Infectious Diseases, Vol. 152, No. 6, 1985, p. 1283-1289.

Research output: Contribution to journalArticle

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