Cellular immunity in q fever: Specific lymphocyte unresponsiveness in q fever endocarditis

Frederick T. Koster, Jim C. Williams, James S. Goodwin

Research output: Contribution to journalLetter

59 Scopus citations

Abstract

Human infection with the rickettsia Coxiella burnetii presents as actue influenza-like primary Q fever, subacute granulomatous hepatitis, or chronic endocarditis with hepatitis. To investigate whether persistent infection is associated with a possible immunologic defect, we tested lymphocyte proliferation specific for Coxiella in vitro in peripheral blood mononuclear cells from patients and controls. All four patients with endocarditis had profound lymphocyte unresponsiveness to Coxiella antigens with normal proliferation to control antigens. Hepatitis and primary Q fever were associated with vigorous responses in vitro to Coxiella antigens. Suppression of lymphocyte unresponsiveness was in part mediated by an antigen-nonspecific, glass-adherent cell. We hypothesize that specific T cell unresponsiveness is an important factor in persistent infection with C burnetii and offer in vitro lymphocyte stimulation as a more specific diagnostic test to distinguish cases of endocarditis among those with chronic hepatitis due to Q fever.

Original languageEnglish (US)
Pages (from-to)1283-1289
Number of pages7
JournalJournal of Infectious Diseases
Volume152
Issue number6
DOIs
StatePublished - Dec 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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