Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

Sisir K. Chattopadhyay, Miles W. Cloyd, David L. Linemeyer, Marilyn R. Lander, Elaine Rands, Douglas R. Lowy

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Abstract

Embryo DNA of AKR mice contains several copies of intact mink cell focus-forming (MCF)-like env gene sequences with a proviral structure. In spontaneous thymic tumours, these MCF-like env sequences have regularly recombined with a specific region of the 3′ end of ecotropic env. This specific recombination is probably a critical event in the pathogenesis of spontaneous AKR tumours.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalNature
Volume295
Issue number5844
DOIs
StatePublished - Dec 1 1982

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    Chattopadhyay, S. K., Cloyd, M. W., Linemeyer, D. L., Lander, M. R., Rands, E., & Lowy, D. R. (1982). Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. Nature, 295(5844), 25-31. https://doi.org/10.1038/295025a0