Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

Sisir K. Chattopadhyay, Miles W. Cloyd, David L. Linemeyer, Marilyn R. Lander, Elaine Rands, Douglas R. Lowy

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Embryo DNA of AKR mice contains several copies of intact mink cell focus-forming (MCF)-like env gene sequences with a proviral structure. In spontaneous thymic tumours, these MCF-like env sequences have regularly recombined with a specific region of the 3′ end of ecotropic env. This specific recombination is probably a critical event in the pathogenesis of spontaneous AKR tumours.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalNature
Volume295
Issue number5844
DOIs
StatePublished - 1982

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Mink
Lymphoma
Inbred AKR Mouse
Thymus Neoplasms
Viruses
env Genes
Genetic Recombination
Embryonic Structures
DNA
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Chattopadhyay, S. K., Cloyd, M. W., Linemeyer, D. L., Lander, M. R., Rands, E., & Lowy, D. R. (1982). Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. Nature, 295(5844), 25-31. https://doi.org/10.1038/295025a0

Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. / Chattopadhyay, Sisir K.; Cloyd, Miles W.; Linemeyer, David L.; Lander, Marilyn R.; Rands, Elaine; Lowy, Douglas R.

In: Nature, Vol. 295, No. 5844, 1982, p. 25-31.

Research output: Contribution to journalArticle

Chattopadhyay, SK, Cloyd, MW, Linemeyer, DL, Lander, MR, Rands, E & Lowy, DR 1982, 'Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas', Nature, vol. 295, no. 5844, pp. 25-31. https://doi.org/10.1038/295025a0
Chattopadhyay SK, Cloyd MW, Linemeyer DL, Lander MR, Rands E, Lowy DR. Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. Nature. 1982;295(5844):25-31. https://doi.org/10.1038/295025a0
Chattopadhyay, Sisir K. ; Cloyd, Miles W. ; Linemeyer, David L. ; Lander, Marilyn R. ; Rands, Elaine ; Lowy, Douglas R. / Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. In: Nature. 1982 ; Vol. 295, No. 5844. pp. 25-31.
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