Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

Sisir K. Chattopadhyay, Miles W. Cloyd, David L. Linemeyer, Marilyn R. Lander, Elaine Rands, Douglas R. Lowy

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

Embryo DNA of AKR mice contains several copies of intact mink cell focus-forming (MCF)-like env gene sequences with a proviral structure. In spontaneous thymic tumours, these MCF-like env sequences have regularly recombined with a specific region of the 3′ end of ecotropic env. This specific recombination is probably a critical event in the pathogenesis of spontaneous AKR tumours.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalNature
Volume295
Issue number5844
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • General

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