Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

Sisir K. Chattopadhyay; Miles W. Cloyd; David L. Linemeyer; Marilyn R. Lander; Elaine Rands; Douglas R. Lowy

doi:10.1038/295025a0

Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

Sisir K. Chattopadhyay
, Miles W. Cloyd
, David L. Linemeyer
, Marilyn R. Lander
, Elaine Rands
, Douglas R. Lowy

Research output: Contribution to journal › Article › peer-review

163 Scopus citations

Abstract

Embryo DNA of AKR mice contains several copies of intact mink cell focus-forming (MCF)-like env gene sequences with a proviral structure. In spontaneous thymic tumours, these MCF-like env sequences have regularly recombined with a specific region of the 3′ end of ecotropic env. This specific recombination is probably a critical event in the pathogenesis of spontaneous AKR tumours.

Original language	English (US)
Pages (from-to)	25-31
Number of pages	7
Journal	Nature
Volume	295
Issue number	5844
DOIs	https://doi.org/10.1038/295025a0
State	Published - 1982
Externally published	Yes

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title = "Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas",

abstract = "Embryo DNA of AKR mice contains several copies of intact mink cell focus-forming (MCF)-like env gene sequences with a proviral structure. In spontaneous thymic tumours, these MCF-like env sequences have regularly recombined with a specific region of the 3′ end of ecotropic env. This specific recombination is probably a critical event in the pathogenesis of spontaneous AKR tumours.",

author = "Chattopadhyay, \{Sisir K.\} and Cloyd, \{Miles W.\} and Linemeyer, \{David L.\} and Lander, \{Marilyn R.\} and Elaine Rands and Lowy, \{Douglas R.\}",

year = "1982",

doi = "10.1038/295025a0",

language = "English (US)",

volume = "295",

pages = "25--31",

journal = "Nature",

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T1 - Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

AU - Chattopadhyay, Sisir K.

AU - Cloyd, Miles W.

AU - Linemeyer, David L.

AU - Lander, Marilyn R.

AU - Rands, Elaine

AU - Lowy, Douglas R.

PY - 1982

Y1 - 1982

N2 - Embryo DNA of AKR mice contains several copies of intact mink cell focus-forming (MCF)-like env gene sequences with a proviral structure. In spontaneous thymic tumours, these MCF-like env sequences have regularly recombined with a specific region of the 3′ end of ecotropic env. This specific recombination is probably a critical event in the pathogenesis of spontaneous AKR tumours.

AB - Embryo DNA of AKR mice contains several copies of intact mink cell focus-forming (MCF)-like env gene sequences with a proviral structure. In spontaneous thymic tumours, these MCF-like env sequences have regularly recombined with a specific region of the 3′ end of ecotropic env. This specific recombination is probably a critical event in the pathogenesis of spontaneous AKR tumours.

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UR - https://www.scopus.com/pages/publications/0020035912#tab=citedBy

U2 - 10.1038/295025a0

DO - 10.1038/295025a0

M3 - Article

C2 - 6276750

AN - SCOPUS:0020035912

SN - 0028-0836

VL - 295

SP - 25

EP - 31

JO - Nature

JF - Nature

IS - 5844

ER -

Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

Abstract

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