Cellular production of a counterfeit viral protein confers immunity to infection by a related virus

Benjamin E. Warner, Matthew J. Ballinger, Pradeep Yerramsetty, Jennifer Reed, Derek J. Taylor, Thomas Smith, Jeremy A. Bruenn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

DNA copies of many non-retroviral RNA virus genes or portions thereof (NIRVs) are present in the nuclear genomes of many eukaryotes. These have often been preserved for millions of years of evolution, suggesting that they play an important cellular function. One possible function is resistance to infection by related viruses. In some cases, this appears to occur through the piRNA system, but in others by way of counterfeit viral proteins encoded by NIRVs. In the fungi, NIRVs may be as long as 1,400 uninterrupted codons. In one such case in the yeast Debaryomyces hansenii, one of these genes provides immunity to a related virus by virtue of expression of a counterfeit viral capsid protein, which interferes with assembly of viral capsids by negative complementation. The widespread occurrence of non-retroviral RNA virus genes in eukaryotes may reflect an underappreciated method of host resistance to infection. This work demonstrates for the first time that an endogenous host protein encoded by a gene that has been naturally acquired from a virus and fixed in a eukaryote can interfere with the replication of a related virus and do so by negative complementation.

Original languageEnglish (US)
Article numbere5679
JournalPeerJ
Volume2018
Issue number9
DOIs
StatePublished - Jan 1 2018

Fingerprint

viral proteins
Viral Proteins
Viruses
Immunity
immunity
Eukaryota
eukaryotic cells
Genes
viruses
RNA Viruses
Infection
infection
genes
Debaryomyces hansenii
Virus Assembly
capsid
Capsid
Capsid Proteins
Virus Diseases
coat proteins

Keywords

  • Endogenous non-retroviral RNA virus
  • Mycovirus
  • NIRV
  • Totivirus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Warner, B. E., Ballinger, M. J., Yerramsetty, P., Reed, J., Taylor, D. J., Smith, T., & Bruenn, J. A. (2018). Cellular production of a counterfeit viral protein confers immunity to infection by a related virus. PeerJ, 2018(9), [e5679]. https://doi.org/10.7717/peerj.5679

Cellular production of a counterfeit viral protein confers immunity to infection by a related virus. / Warner, Benjamin E.; Ballinger, Matthew J.; Yerramsetty, Pradeep; Reed, Jennifer; Taylor, Derek J.; Smith, Thomas; Bruenn, Jeremy A.

In: PeerJ, Vol. 2018, No. 9, e5679, 01.01.2018.

Research output: Contribution to journalArticle

Warner, BE, Ballinger, MJ, Yerramsetty, P, Reed, J, Taylor, DJ, Smith, T & Bruenn, JA 2018, 'Cellular production of a counterfeit viral protein confers immunity to infection by a related virus', PeerJ, vol. 2018, no. 9, e5679. https://doi.org/10.7717/peerj.5679
Warner, Benjamin E. ; Ballinger, Matthew J. ; Yerramsetty, Pradeep ; Reed, Jennifer ; Taylor, Derek J. ; Smith, Thomas ; Bruenn, Jeremy A. / Cellular production of a counterfeit viral protein confers immunity to infection by a related virus. In: PeerJ. 2018 ; Vol. 2018, No. 9.
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