TY - JOUR
T1 - Cellulose acetate butyrate/poly(caprolactonetriol) blends
T2 - Miscibility, mechanical properties, and in vivo inflammatory response
AU - Kanis, Luiz A.
AU - Marques, Ellen L.
AU - Zepon, Karine M.
AU - Pereira, Jefferson R.
AU - Pamato, Saulo
AU - De Oliveira, Marcelo T.
AU - Danielski, Lucinéia G.
AU - Petronilho, Fabricia C.
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2014/11/11
Y1 - 2014/11/11
N2 - This study reports the results of the characterization of cellulose acetate butyrate and polycaprolactone-triol blends in terms of miscibility, swelling capacity, mechanical properties, and inflammatory response in vivo. The cellulose acetate butyrate film was opaque and rigid, with glass transition (Tg) at 134° and melting temperature of 156°. The cellulose acetate butyrate/polycaprolactone-triol films were transparent up to a polycaprolactone-triol content of 60%. Tg of the cellulose acetate butyrate films decreased monotonically as polycaprolactone-triol was added to the blend, thus indicating miscibility. FTIR spectroscopy revealed a decrease in intramolecular hydrogen bonding in polycaprolactone-triol, whereas no hydrogen bonding was observed between cellulose acetate butyrate and -OH from polycaprolactone-triol. The increase in polycaprolactone-triol content in the blend decreased the water uptake. An increase in polycaprolactone-triol content decreased the modulus of elasticity and increased the elongation at break. A cellulose acetate butyrate/polycaprolactone-triol 70/30 blend implanted in rats showed only an acute inflammatory response 7 days after surgery. No change in inflammation mediators was observed.
AB - This study reports the results of the characterization of cellulose acetate butyrate and polycaprolactone-triol blends in terms of miscibility, swelling capacity, mechanical properties, and inflammatory response in vivo. The cellulose acetate butyrate film was opaque and rigid, with glass transition (Tg) at 134° and melting temperature of 156°. The cellulose acetate butyrate/polycaprolactone-triol films were transparent up to a polycaprolactone-triol content of 60%. Tg of the cellulose acetate butyrate films decreased monotonically as polycaprolactone-triol was added to the blend, thus indicating miscibility. FTIR spectroscopy revealed a decrease in intramolecular hydrogen bonding in polycaprolactone-triol, whereas no hydrogen bonding was observed between cellulose acetate butyrate and -OH from polycaprolactone-triol. The increase in polycaprolactone-triol content in the blend decreased the water uptake. An increase in polycaprolactone-triol content decreased the modulus of elasticity and increased the elongation at break. A cellulose acetate butyrate/polycaprolactone-triol 70/30 blend implanted in rats showed only an acute inflammatory response 7 days after surgery. No change in inflammation mediators was observed.
KW - blend
KW - Cellulose acetate butyrate
KW - inflammatory
KW - miscibility
KW - polycaprolactone-triol
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U2 - 10.1177/0885328214542488
DO - 10.1177/0885328214542488
M3 - Article
C2 - 25015652
AN - SCOPUS:84908886238
SN - 0885-3282
VL - 29
SP - 654
EP - 661
JO - Journal of Biomaterials Applications
JF - Journal of Biomaterials Applications
IS - 5
ER -