Cellulose acetate butyrate/poly(caprolactonetriol) blends: Miscibility, mechanical properties, and in vivo inflammatory response

Luiz A. Kanis, Ellen L. Marques, Karine M. Zepon, Jefferson R. Pereira, Saulo Pamato, Marcelo T. De Oliveira, Lucinéia G. Danielski, Fabricia C. Petronilho

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

This study reports the results of the characterization of cellulose acetate butyrate and polycaprolactone-triol blends in terms of miscibility, swelling capacity, mechanical properties, and inflammatory response in vivo. The cellulose acetate butyrate film was opaque and rigid, with glass transition (Tg) at 134° and melting temperature of 156°. The cellulose acetate butyrate/polycaprolactone-triol films were transparent up to a polycaprolactone-triol content of 60%. Tg of the cellulose acetate butyrate films decreased monotonically as polycaprolactone-triol was added to the blend, thus indicating miscibility. FTIR spectroscopy revealed a decrease in intramolecular hydrogen bonding in polycaprolactone-triol, whereas no hydrogen bonding was observed between cellulose acetate butyrate and -OH from polycaprolactone-triol. The increase in polycaprolactone-triol content in the blend decreased the water uptake. An increase in polycaprolactone-triol content decreased the modulus of elasticity and increased the elongation at break. A cellulose acetate butyrate/polycaprolactone-triol 70/30 blend implanted in rats showed only an acute inflammatory response 7 days after surgery. No change in inflammation mediators was observed.

Original languageEnglish (US)
Pages (from-to)654-661
Number of pages8
JournalJournal of Biomaterials Applications
Volume29
Issue number5
DOIs
StatePublished - Nov 11 2014
Externally publishedYes

Keywords

  • blend
  • Cellulose acetate butyrate
  • inflammatory
  • miscibility
  • polycaprolactone-triol

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Fingerprint

Dive into the research topics of 'Cellulose acetate butyrate/poly(caprolactonetriol) blends: Miscibility, mechanical properties, and in vivo inflammatory response'. Together they form a unique fingerprint.

Cite this