Central and peripheral circadian oscillators in Drosophila

Paul E. Hardin, Balaji Krishnan, Jerry H. Houl, Hao Zheng, Fanny S. Ng, Stuart E. Dryer, Nick R J Glossop

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

Drosophila circadian oscillators comprise interlocked period(per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops. Within these feedback loops, CLOCK (CLK) and CYCLE (CYC) bind E-box elements to activate per and tim transcription, and we now show that at the same time CLK-CYC repress Clk by activating the transcriptional repressor vrille (vri), thus accounting for the opposite cycling phases of these transcripts and identifying vri as the negative component of the Clk-feedback-loop. The core oscillator mechanism is assumed to be the same for oscillators in different tissues. However, we have shown that CRYPTOCHROME (CRY) has a light-independent function in the oscillator that controls olfaction rhythms, suggesting that CRY may function within the oscillator mechanism itself as it does in mammals. These olfaction rhythms require the function of 'peripheral' oscillators which are distinct from the 'central' lateral neuron (LN) oscillators that mediate locomotor activity rhythms. Preliminary results show that antennal oscillator cells are sufficient and LNs are not necessary for olfaction rhythms, indicating that unlike the situation in mammals, the central oscillator has little impact on the olfaction rhythm oscillator under these conditions.

Original languageEnglish
Title of host publicationNovartis Foundation Symposium
Pages140-160
Number of pages21
Volume253
StatePublished - 2003
Externally publishedYes

Publication series

NameNovartis Foundation Symposium
Volume253

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hardin, P. E., Krishnan, B., Houl, J. H., Zheng, H., Ng, F. S., Dryer, S. E., & Glossop, N. R. J. (2003). Central and peripheral circadian oscillators in Drosophila. In Novartis Foundation Symposium (Vol. 253, pp. 140-160). (Novartis Foundation Symposium; Vol. 253).