Central and peripheral hypersensitivity in the irritable bowel syndrome

QiQi Zhou, Roger B. Fillingim, Joseph L. Riley, William B. Malarkey, G. Nicholas Verne

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Previous investigations of somatic hypersensitivity in IBS patients have typically involved only a single stimulus modality, and little information exists regarding whether patterns of somatic pain perception vary across stimulus modalities within a group of patients with IBS. Therefore, the current study was designed to characterize differences in perceptual responses to a battery of noxious somatic stimuli in IBS patients compared to controls. A total of 78 diarrhea-predominant and 57 controls participated in the study. We evaluated pain threshold and tolerance and sensory and affective ratings of contact thermal, mechanical pressure, ischemic stimuli, and cold pressor stimuli. In addition to assessing perceptual responses, we also evaluated differences in neuroendocrine and cardiovascular responses to these experimental somatic pain stimuli. A subset of IBS patients demonstrated the presence of somatic hypersensitivity to thermal, ischemic, and cold pressor nociceptive stimuli. The somatic hypersensitivity in IBS patients was somatotopically organized in that the lower extremities that share viscerosomatic convergence with the colon demonstrate the greatest hypersensitivity. There were also changes in ACTH, cortisol, and systolic blood pressure in response to the ischemic pain testing in IBS patients when compared to controls. The results of this study suggest that a more widespread alteration in central pain processing in a subset of IBS patients may be present as they display hypersensitivity to heat, ischemic, and cold pressor stimuli.

Original languageEnglish (US)
Pages (from-to)454-461
Number of pages8
JournalPain
Volume148
Issue number3
DOIs
StatePublished - Mar 2010

Fingerprint

Irritable Bowel Syndrome
Hypersensitivity
Nociceptive Pain
Hot Temperature
Blood Pressure
Pain
Pain Perception
Pain Threshold
Adrenocorticotropic Hormone
Hydrocortisone
Lower Extremity
Diarrhea
Colon
Pressure

Keywords

  • Cold pressor pain threshold and tolerance (CPTh and CPTo)
  • Heat pain threshold and tolerance (HPTh and HPTo)
  • Irritable bowel syndrome (IBS)
  • Ischemic pain threshold and tolerance (IPTh and IPTo)
  • Pressure (mechanical) pain threshold (PPT)

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Neurology
  • Pharmacology

Cite this

Zhou, Q., Fillingim, R. B., Riley, J. L., Malarkey, W. B., & Verne, G. N. (2010). Central and peripheral hypersensitivity in the irritable bowel syndrome. Pain, 148(3), 454-461. https://doi.org/10.1016/j.pain.2009.12.005

Central and peripheral hypersensitivity in the irritable bowel syndrome. / Zhou, QiQi; Fillingim, Roger B.; Riley, Joseph L.; Malarkey, William B.; Verne, G. Nicholas.

In: Pain, Vol. 148, No. 3, 03.2010, p. 454-461.

Research output: Contribution to journalArticle

Zhou, Q, Fillingim, RB, Riley, JL, Malarkey, WB & Verne, GN 2010, 'Central and peripheral hypersensitivity in the irritable bowel syndrome', Pain, vol. 148, no. 3, pp. 454-461. https://doi.org/10.1016/j.pain.2009.12.005
Zhou Q, Fillingim RB, Riley JL, Malarkey WB, Verne GN. Central and peripheral hypersensitivity in the irritable bowel syndrome. Pain. 2010 Mar;148(3):454-461. https://doi.org/10.1016/j.pain.2009.12.005
Zhou, QiQi ; Fillingim, Roger B. ; Riley, Joseph L. ; Malarkey, William B. ; Verne, G. Nicholas. / Central and peripheral hypersensitivity in the irritable bowel syndrome. In: Pain. 2010 ; Vol. 148, No. 3. pp. 454-461.
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