Central nervous system pseudallescheriasis after near-drowning

Kessarin Panichpisal, Kenneth Nugent, Juan Sarria

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Clinical characteristics of central nervous system (CNS) pseudallescheriasis after near-drowning have not been systematically analyzed. Methods: Review of cases reported in the English-language literature. Results: Sixteen patients were identified. The average period between the near-drowning episode and onset of clinical manifestations was 37 days. Common manifestations included fever, altered mental status, headache, seizures, and hemiparesis. All patients developed brain abscesses; however, imaging studies were normal at presentation in 6 patients. Cerebrospinal fluid neutrophilic pleocytosis, elevated protein, and decreased glucose were commonly observed. Most patients were treated with surgical resection and systemic amphotericin B or miconazole. Voriconazole was used in 2 patients. Twelve patients (75%) died. The average time between the near-drowning episode and death was 12 weeks. Four survivors received prompt treatment. Conclusions: CNS pseudallescheriasis after near-drowning is highly lethal. Early diagnosis and aggressive medical and surgical interventions may improve survival.

Original languageEnglish (US)
Pages (from-to)348-352
Number of pages5
JournalClinical Neurology and Neurosurgery
Volume108
Issue number4
DOIs
StatePublished - Jun 2006

Fingerprint

Near Drowning
Central Nervous System
Miconazole
Brain Abscess
Leukocytosis
Amphotericin B
Paresis
Headache
Survivors
Cerebrospinal Fluid
Early Diagnosis
Seizures
Fever
Language
Glucose
Survival

Keywords

  • CNS infection
  • Near-drowning
  • Pseudallescheria boydii

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Neurology

Cite this

Central nervous system pseudallescheriasis after near-drowning. / Panichpisal, Kessarin; Nugent, Kenneth; Sarria, Juan.

In: Clinical Neurology and Neurosurgery, Vol. 108, No. 4, 06.2006, p. 348-352.

Research output: Contribution to journalArticle

Panichpisal, Kessarin ; Nugent, Kenneth ; Sarria, Juan. / Central nervous system pseudallescheriasis after near-drowning. In: Clinical Neurology and Neurosurgery. 2006 ; Vol. 108, No. 4. pp. 348-352.
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