Central nervous system recurrence ten years after remission of acute lymphoblastic leukemia

J. E. Schweinle, J. B. Alperin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Therapy with vincristine and prednisone achieved a complete remission in a 10-yr old Caucasian girl with acute lymphoblastic leukemia. Maintenance therapy with 6-mercaptopurine was then administered for 7 yr, but prophylactic intrathecal chemotherapy and central nervous system (CNS) radiation were never given the patient. 10 yr from the time of diagnosis, she presented with signs of increased intracranial pressure and a diagnosis of CNS leukemia was confirmed. At this time, however, no leukemia was detected on examination of her blood and bone marrow. She was successfully treated with intrathecal methotrexate and radiation therapy. After a careful search of the literature it has been concluded that this is the first reported case of such a long remission of acute lymphoblastic leukemia with subsequent relapse.

Original languageEnglish (US)
Pages (from-to)16-18
Number of pages3
JournalCancer
Volume45
Issue number1
StatePublished - 1980

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Central Nervous System
Bone Marrow Examination
Recurrence
6-Mercaptopurine
Intracranial Pressure
Vincristine
Prednisone
Methotrexate
Radiotherapy
Radiation
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Central nervous system recurrence ten years after remission of acute lymphoblastic leukemia. / Schweinle, J. E.; Alperin, J. B.

In: Cancer, Vol. 45, No. 1, 1980, p. 16-18.

Research output: Contribution to journalArticle

Schweinle, JE & Alperin, JB 1980, 'Central nervous system recurrence ten years after remission of acute lymphoblastic leukemia', Cancer, vol. 45, no. 1, pp. 16-18.
Schweinle, J. E. ; Alperin, J. B. / Central nervous system recurrence ten years after remission of acute lymphoblastic leukemia. In: Cancer. 1980 ; Vol. 45, No. 1. pp. 16-18.
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