Central versus peripheral effects of bombesin on the release of gastrointestinal hormones in dogs

Q. ‐H Lu, J. S. Swierczek, X. ‐G Zhu, G. H. Greeley, J. C. Thompson

    Research output: Contribution to journalArticle

    5 Scopus citations

    Abstract

    This study compared the effects of bombesin given intracerebroventicularly and intravenously on circulating levels of gastrin, pancreatic polypeptide (PP), and cholecystokinin (CCK‐33). Bilateral cannulas were implanted permanently into the lateral cerebral ventricles of five dogs. An intravenous (IV) bolus injection of bombesin (0.25 μg/kg) significantly elevated circulating levels of gastrin, PP, and CCK‐33. Vagotomy inhibited the release of PP that was induced by IV bombesin, but vagotomy did not affect gastrin and CCK‐33 responses. Intracerebroventricular injection of bombesin (5.0 μg) significantly elevated circulating gastrin levels but did not affect circulating levels of CCK‐33 and PP. Vagotomy did not alter gastrin release induced by intracerebroventricular injection of bombesin.

    Original languageEnglish (US)
    Pages (from-to)553-559
    Number of pages7
    JournalJournal of Neuroscience Research
    Volume16
    Issue number3
    DOIs
    StatePublished - 1986

    Keywords

    • cholecystokinin
    • gastrin
    • intracerebroventricular
    • pancreatic polypeptide

    ASJC Scopus subject areas

    • Cellular and Molecular Neuroscience

    Fingerprint Dive into the research topics of 'Central versus peripheral effects of bombesin on the release of gastrointestinal hormones in dogs'. Together they form a unique fingerprint.

  • Cite this