Centrifuge-Simulated Suborbital Spaceflight in a Subject with Cardiac Malformation

Rebecca Blue, Eric Blacher, Tarah L. Castleberry, James M. Vanderploeg

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

INTRODUCTION: Commercial spaceflight participants (SFPs) will introduce new medical challenges to the aerospace community, with unique medical conditions never before exposed to the space environment. This is a case report regarding the response of a subject with multiple cardiac malformations, including aortic insufficiency, pulmonary atresia, pulmonary valve replacement, ventricular septal defect (post-repair), and pulmonary artery stenosis (post-dilation), to centrifuge acceleration simulating suborbital flight.

CASE REPORT: A 23-yr-old man with a history of multiple congenital cardiac malformations underwent seven centrifuge runs over 2 d. Day 1 consisted of two +G(z) runs (peak = +3.5 G(z), run 2) and two +G(x) runs (peak = +6.0 G(x), run 4). Day 2 consisted of three runs approximating suborbital spaceflight profiles (combined +G(x) and +G(z)). Data collected included blood pressure, electrocardiogram, pulse oximetry, neurovestibular exams, and post-run questionnaires regarding motion sickness, disorientation, greyout, and other symptoms. Despite the subject's significant medical history, he tolerated the acceleration profiles well and demonstrated no significant abnormal physiological responses.

DISCUSSION: Potential risks to SFPs with aortic insufficiency, artificial heart valves, or valvular insufficiency include lower +G(z) tolerance, earlier symptom onset, and ineffective mitigation strategies such as anti-G straining maneuvers. There are no prior studies of prolonged accelerations approximating spaceflight in such individuals. This case demonstrates tolerance of acceleration profiles in an otherwise young and healthy individual with significant cardiac malformations, suggesting that such conditions may not necessarily preclude participation in commercial spaceflight.

Original languageEnglish (US)
Pages (from-to)999-1003
Number of pages5
JournalAerospace medicine and human performance
Volume86
Issue number11
DOIs
StatePublished - Nov 1 2015

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Space Flight
Motion Sickness
Pulmonary Atresia
Artificial Heart
Pulmonary Valve
Oximetry
Ventricular Heart Septal Defects
Heart Valves
Dilatation
Electrocardiography
Blood Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Centrifuge-Simulated Suborbital Spaceflight in a Subject with Cardiac Malformation. / Blue, Rebecca; Blacher, Eric; Castleberry, Tarah L.; Vanderploeg, James M.

In: Aerospace medicine and human performance, Vol. 86, No. 11, 01.11.2015, p. 999-1003.

Research output: Contribution to journalArticle

Blue, Rebecca ; Blacher, Eric ; Castleberry, Tarah L. ; Vanderploeg, James M. / Centrifuge-Simulated Suborbital Spaceflight in a Subject with Cardiac Malformation. In: Aerospace medicine and human performance. 2015 ; Vol. 86, No. 11. pp. 999-1003.
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