Cerbrospinal fluid immunoglobulin abnormalities in neurosarcoidosis

S. J. Borucki, B. V. Nguyen, T. Ladoulis Ch., R. R. McKendall

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A retrospective chart review of neurosarcoidosis at the University of Texas Medical Branch (Galveston) between 1982 and 1987 revealed 99 patients with sarcoidosis. Six patients were diagnosed with neurosarcoidosis and had electrophoresis of serum and cerebrospinal fluid performed (one patient with ventriculo-peritoneal shunt was later excluded). Cerebrospinal fluid immunoglobulins and albumin levels were determined followed by calculation of an IgG index and synthesis rate for each patient. Four (80%) of five patients had elevated IgG indexes and synthesis rates indicative of intrathecal immunoglubulin production. No patient had immunoglobulin oligoclonal bands detected. To date, results of electrophoresis of cerebrospinal fluid in neurosarcoidosis have been reported in 37 patients among four series. Of these, only nine patients (24%) have had either an elevated IgG index or synthesis rate. Our series suggests that intrathecal immunoglobulin production in neurosarcoidosis occurs more frequently than previously described. Furthermore, the elevated indexes and synthesis rates without associated oligoclonal bands suggests a polyclonal immunoglubulin response.

Original languageEnglish (US)
Pages (from-to)270-273
Number of pages4
JournalArchives of Neurology
Volume46
Issue number3
StatePublished - 1989

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Immunoglobulins
Oligoclonal Bands
Cerebrospinal Fluid
Immunoglobulin G
Electrophoresis
Ventriculoperitoneal Shunt
Neurosarcoidosis
Sarcoidosis
Albumins
Serum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Borucki, S. J., Nguyen, B. V., Ladoulis Ch., T., & McKendall, R. R. (1989). Cerbrospinal fluid immunoglobulin abnormalities in neurosarcoidosis. Archives of Neurology, 46(3), 270-273.

Cerbrospinal fluid immunoglobulin abnormalities in neurosarcoidosis. / Borucki, S. J.; Nguyen, B. V.; Ladoulis Ch., T.; McKendall, R. R.

In: Archives of Neurology, Vol. 46, No. 3, 1989, p. 270-273.

Research output: Contribution to journalArticle

Borucki, SJ, Nguyen, BV, Ladoulis Ch., T & McKendall, RR 1989, 'Cerbrospinal fluid immunoglobulin abnormalities in neurosarcoidosis', Archives of Neurology, vol. 46, no. 3, pp. 270-273.
Borucki SJ, Nguyen BV, Ladoulis Ch. T, McKendall RR. Cerbrospinal fluid immunoglobulin abnormalities in neurosarcoidosis. Archives of Neurology. 1989;46(3):270-273.
Borucki, S. J. ; Nguyen, B. V. ; Ladoulis Ch., T. ; McKendall, R. R. / Cerbrospinal fluid immunoglobulin abnormalities in neurosarcoidosis. In: Archives of Neurology. 1989 ; Vol. 46, No. 3. pp. 270-273.
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