Cerebral blood oxygenation measurements in neonates with optoacoustic technique

Stephen Herrmann, Irene Y. Petrov, Yuriy Petrov, Carol Richardson, Rafael Fonseca, Donald Prough, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Cerebral hypoxia is a major contributor to neonatal/infant mortality and morbidity including severe neurological complications such as mental retardation, cerebral palsy, motor impairment, and epilepsy. Currently, no technology is capable of accurate monitoring of neonatal cerebral oxygenation. We proposed to use optoacoustics for this application by probing the superior sagittal sinus (SSS), a large central cerebral vein. We developed and built a multi-wavelength, optical parametric oscillator (OPO) and laser diode optoacoustic systems for measurement of SSS blood oxygenation in the reflection mode through open anterior or posterior fontanelles and in the transmission mode through the skull in the occipital area. In this paper we present results of initial tests of the laser diode system for neonatal cerebral oxygenation measurements. First, the system was tested in phantoms simulating neonatal SSS. Then, using the data obtained in the phantoms, we optimized the system's hardware and software and tested it in neonates admitted in the Neonatal Intensive Care Unit. The laser diode system was capable of detecting SSS signals in the reflection mode through the open anterior and posterior fontanelles as well as in the transmission mode through the skull with high signal-to-noise ratio. Using the signals measured at different wavelengths and algorithms developed for oxygenation measurements, the laser diode system provided real-time, continuous oxygenation monitoring with high precision at all these locations.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound: Imaging and Sensing 2017
PublisherSPIE
Volume10064
ISBN (Electronic)9781510605695
DOIs
StatePublished - 2017
EventPhotons Plus Ultrasound: Imaging and Sensing 2017 - San Francisco, United States
Duration: Jan 29 2017Feb 1 2017

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2017
CountryUnited States
CitySan Francisco
Period1/29/172/1/17

Fingerprint

Photoacoustic Techniques
Cranial Fontanelles
Superior Sagittal Sinus
Semiconductor Lasers
Oxygenation
Photoacoustic effect
oxygenation
sinuses
blood
Blood
Semiconductor lasers
semiconductor lasers
Infant Mortality
skull
Skull
Cerebral Veins
Brain Hypoxia
Neonatal Intensive Care Units
epilepsy
Computer Systems

Keywords

  • Cerebral ischemia
  • Cerebral oxygenation
  • Imaging
  • Neonatal
  • Noninvasive monitoring
  • Optoacoustic

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Herrmann, S., Petrov, I. Y., Petrov, Y., Richardson, C., Fonseca, R., Prough, D., & Esenaliev, R. (2017). Cerebral blood oxygenation measurements in neonates with optoacoustic technique. In Photons Plus Ultrasound: Imaging and Sensing 2017 (Vol. 10064). [100640Q] SPIE. https://doi.org/10.1117/12.2256170

Cerebral blood oxygenation measurements in neonates with optoacoustic technique. / Herrmann, Stephen; Petrov, Irene Y.; Petrov, Yuriy; Richardson, Carol; Fonseca, Rafael; Prough, Donald; Esenaliev, Rinat.

Photons Plus Ultrasound: Imaging and Sensing 2017. Vol. 10064 SPIE, 2017. 100640Q.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Herrmann, S, Petrov, IY, Petrov, Y, Richardson, C, Fonseca, R, Prough, D & Esenaliev, R 2017, Cerebral blood oxygenation measurements in neonates with optoacoustic technique. in Photons Plus Ultrasound: Imaging and Sensing 2017. vol. 10064, 100640Q, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2017, San Francisco, United States, 1/29/17. https://doi.org/10.1117/12.2256170
Herrmann S, Petrov IY, Petrov Y, Richardson C, Fonseca R, Prough D et al. Cerebral blood oxygenation measurements in neonates with optoacoustic technique. In Photons Plus Ultrasound: Imaging and Sensing 2017. Vol. 10064. SPIE. 2017. 100640Q https://doi.org/10.1117/12.2256170
Herrmann, Stephen ; Petrov, Irene Y. ; Petrov, Yuriy ; Richardson, Carol ; Fonseca, Rafael ; Prough, Donald ; Esenaliev, Rinat. / Cerebral blood oxygenation measurements in neonates with optoacoustic technique. Photons Plus Ultrasound: Imaging and Sensing 2017. Vol. 10064 SPIE, 2017.
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