Abstract
Immune checkpoint inhibitor (ICI) mediated encephalitides are increasingly being recognized in the literature, but atypical cases may be missed or misdiagnosed. Recent efforts are directed to identify biomarkers to help elucidate early diagnosis and treatment. Herein, we describe two cases of antibody negative ICI-mediated encephalitis with elevated serum Neurofilament light chain (sNfL) levels. Practical Implication: Baseline and longitudinal measurements of serum neurofilament light chains can help determine treatment strategies and prognosis in patients with suspected immune checkpoint inhibitor encephalitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 242-244 |
| Number of pages | 3 |
| Journal | Oxford Medical Case Reports |
| Volume | 2024 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2024 |
| Externally published | Yes |
Keywords
- Immune checkpoint inhibitors
- encephalitis
- neurofilament light chain
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Infectious Diseases
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