Cerebral hemodynamics after hemorrhagic shock: Effects of the type of resuscitation fluid

G. V. Poole, J. C. Johnson, Donald Prough, D. A. Stump, E. H. Stullken

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cerebral blood flow (CBF), cerebral oxygen delivery, and intracranial pressure were measured in 12 dogs subjected to hemorrhagic shock and then resuscitated with lactated Ringer's solution or 6% hetastarch. Hemorrhagic shock was produced by the rapid removal of blood to achieve a mean arterial pressure (MAP) of 40 mm Hg with BP maintained at that level for 30 min. Six animals were resuscitated with lactated Ringer's solution, 60 ml/kg iv, and six with 6% hetastarch, 20 ml/kg iv. Both solutions effectively restored systemic hemodynamic stability, increasing cardiac output and MAP. Intracranial pressure was significantly (p < .05) lower after resuscitation in the hetastarch group, but CBF, which had decreased during shock, was not normalized by either fluid, and cerebral oxygen transport fell further with resuscitation secondary to a hemodilutional reduction of hemoglobin. Although 6% hetastarch may improve systemic hemodynamics and maintain a low intracranial pressure during resuscitation, it fails, as does lactated Ringer's solution, to restore cerebral oxygen transport to prehemorrhagic shock levels.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalCritical Care Medicine
Volume14
Issue number7
StatePublished - 1986
Externally publishedYes

Fingerprint

Hydroxyethyl Starch Derivatives
Hemorrhagic Shock
Resuscitation
Cerebrovascular Circulation
Intracranial Pressure
Hemodynamics
Oxygen
Shock
Arterial Pressure
Cardiac Output
Hemoglobins
Dogs
Ringer's solution
Ringer's lactate

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Poole, G. V., Johnson, J. C., Prough, D., Stump, D. A., & Stullken, E. H. (1986). Cerebral hemodynamics after hemorrhagic shock: Effects of the type of resuscitation fluid. Critical Care Medicine, 14(7), 629-633.

Cerebral hemodynamics after hemorrhagic shock : Effects of the type of resuscitation fluid. / Poole, G. V.; Johnson, J. C.; Prough, Donald; Stump, D. A.; Stullken, E. H.

In: Critical Care Medicine, Vol. 14, No. 7, 1986, p. 629-633.

Research output: Contribution to journalArticle

Poole, GV, Johnson, JC, Prough, D, Stump, DA & Stullken, EH 1986, 'Cerebral hemodynamics after hemorrhagic shock: Effects of the type of resuscitation fluid', Critical Care Medicine, vol. 14, no. 7, pp. 629-633.
Poole, G. V. ; Johnson, J. C. ; Prough, Donald ; Stump, D. A. ; Stullken, E. H. / Cerebral hemodynamics after hemorrhagic shock : Effects of the type of resuscitation fluid. In: Critical Care Medicine. 1986 ; Vol. 14, No. 7. pp. 629-633.
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