Cerebral perfusion and neuropsychological consequences of chronic cocaine use

T. L. Strickland, I. Mena, Javier Villanueva-Meyer, B. L. Miller, J. Cummings, C. M. Mehringer, P. Satz, H. Myers

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Abstract

Research indicates that cocaine significantly constricts the cerebral vasculature and can lead to ischemic brain infarction. Long-term effects of intermittent or casual cocaine use in patients without symptoms of stroke or transient ischemic attack were investigated. Single-photon emission computed tomography with xenon-133 and [99mTc]hexamethylpropyleneamine oxime, magnetic resonance imaging, and selected neuropsychological measures were used to study cerebral perfusion, brain morphology, and cognitive functioning. Patients were drug free for at least 6 months before evaluation. All showed regions of significant cerebral hypoperfusion in the frontal, periventricular, and/or temporal-parietal areas. Deficits in attention, concentration, new learning, visual and verbal memory, word production, and visuomotor integration were observed. This study indicates that long-term cocaine use may produce sustained brain perfusion deficits and persistent neuropsychological compromise in some subgroups of cocaine-abusing patients.

Original languageEnglish (US)
Pages (from-to)419-427
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume5
Issue number4
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Strickland, T. L., Mena, I., Villanueva-Meyer, J., Miller, B. L., Cummings, J., Mehringer, C. M., Satz, P., & Myers, H. (1993). Cerebral perfusion and neuropsychological consequences of chronic cocaine use. Journal of Neuropsychiatry and Clinical Neurosciences, 5(4), 419-427. https://doi.org/10.1176/jnp.5.4.419