Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system

Andrey Petrov, Donald Prough, Irene Y. Petrov, Yuriy Petrov, Donald J. Deyo, Sheryl N. Henkel, Roger Seeton, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Monitoring of cerebral venous oxygenation is useful to facilitate management of patients with severe or moderate traumatic brain injury (TBI). Prompt recognition of low cerebral venous oxygenation is a key to avoiding secondary brain injury associated with brain hypoxia. In specialized clinical research centers, jugular venous bulb catheters have been used for cerebral venous oxygenation monitoring and have demonstrated that oxygen saturation < 50% (normal range is 55-75%) correlates with poor clinical outcome. We developed an optoacoustic technique for noninvasive monitoring of cerebral venous oxygenation. Recently, we designed and built a novel, medical grade optoacoustic system operating in the near-infrared spectral range for continuous, real-time oxygenation monitoring in the superior sagittal sinus (SSS), a large central cerebral vein. In this work, we designed and built a novel SSS optoacoustic probe and developed a new algorithm for SSS oxygenation measurement. The SSS signals were measured in healthy volunteers during voluntary hyperventilation, which induced changes in SSS oxygenation. Simultaneously, we measured exhaled carbon dioxide concentration (EtCO2) using capnography. Good temporal correlation between decreases in optoacoustically measured SSS oxygenation and decreases in EtCO2 was obtained. Decreases in EtCO2 from normal values (35-45 mmHg) to 20-25 mmHg resulted in SSS oxygenation decreases by 3-10%. Intersubject variability of the responses may relate to nonspecific brain activation associated with voluntary hyperventilation. The obtained data demonstrate the capability of the optoacoustic system to detect in real time minor changes in the SSS blood oxygenation.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8581
DOIs
StatePublished - 2013
EventPhotons Plus Ultrasound: Imaging and Sensing 2013 - San Francisco, CA, United States
Duration: Feb 3 2013Feb 5 2013

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2013
CountryUnited States
CitySan Francisco, CA
Period2/3/132/5/13

Fingerprint

hyperventilation
Superior Sagittal Sinus
Oxygenation
Hyperventilation
Photoacoustic effect
oxygenation
sinuses
blood
Healthy Volunteers
Blood
Monitoring
Brain
brain damage
Photoacoustic Techniques
Reference Values
Capnography
brain
Cerebral Veins
Brain Hypoxia
carbon dioxide concentration

Keywords

  • cerebral blood oxygenation
  • clinical applications
  • hypocapnia
  • hypoxia
  • noninvasive monitoring
  • optoacoustics
  • photoacoustics
  • traumatic brain injury

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Petrov, A., Prough, D., Petrov, I. Y., Petrov, Y., Deyo, D. J., Henkel, S. N., ... Esenaliev, R. (2013). Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8581). [85814Z] https://doi.org/10.1117/12.2010438

Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system. / Petrov, Andrey; Prough, Donald; Petrov, Irene Y.; Petrov, Yuriy; Deyo, Donald J.; Henkel, Sheryl N.; Seeton, Roger; Esenaliev, Rinat.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8581 2013. 85814Z.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Petrov, A, Prough, D, Petrov, IY, Petrov, Y, Deyo, DJ, Henkel, SN, Seeton, R & Esenaliev, R 2013, Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8581, 85814Z, Photons Plus Ultrasound: Imaging and Sensing 2013, San Francisco, CA, United States, 2/3/13. https://doi.org/10.1117/12.2010438
Petrov A, Prough D, Petrov IY, Petrov Y, Deyo DJ, Henkel SN et al. Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8581. 2013. 85814Z https://doi.org/10.1117/12.2010438
Petrov, Andrey ; Prough, Donald ; Petrov, Irene Y. ; Petrov, Yuriy ; Deyo, Donald J. ; Henkel, Sheryl N. ; Seeton, Roger ; Esenaliev, Rinat. / Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8581 2013.
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