CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY

Ralph A. Lord; Randall M. Goldblum; Phillip M. Forman; Elton Dupree; Wray D. Storey; Armond S. Goldman

doi:10.1016/S0140-6736(73)92349-0

CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY

Ralph A. Lord, Randall M. Goldblum, Phillip M. Forman, Elton Dupree, Wray D. Storey, Armond S. Goldman

Pediatrics

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13 Scopus citations

Abstract

The case of a male with a late-onset type of combined immunodeficiency and a chronic progressive encephalopathy is reported. In this case serum IgM was undetected but cerebrospinal-fluid (C.S.F.) IgM was demonstrated which appeared to be similar to the normal polymeric form of IgM. This occurrence of IgM in the C.S.F. did not appear to be due to disruption of the blood/brain barrier, since other large-molecular-weight serum-proteins such as alpha-2-macroglobulins and fibrinogen were absent from the C.S.F. Therefore, it appears that the C.S.F. IgM may have been produced by lymphoid cells in the brain.

Original language	English (US)
Pages (from-to)	528-529
Number of pages	2
Journal	The Lancet
Volume	302
Issue number	7828
DOIs	https://doi.org/10.1016/S0140-6736(73)92349-0
State	Published - Sep 8 1973

ASJC Scopus subject areas

General Medicine

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title = "CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY",

abstract = "The case of a male with a late-onset type of combined immunodeficiency and a chronic progressive encephalopathy is reported. In this case serum IgM was undetected but cerebrospinal-fluid (C.S.F.) IgM was demonstrated which appeared to be similar to the normal polymeric form of IgM. This occurrence of IgM in the C.S.F. did not appear to be due to disruption of the blood/brain barrier, since other large-molecular-weight serum-proteins such as alpha-2-macroglobulins and fibrinogen were absent from the C.S.F. Therefore, it appears that the C.S.F. IgM may have been produced by lymphoid cells in the brain.",

author = "Lord, {Ralph A.} and Goldblum, {Randall M.} and Forman, {Phillip M.} and Elton Dupree and Storey, {Wray D.} and Goldman, {Armond S.}",

year = "1973",

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T1 - CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY

AU - Lord, Ralph A.

AU - Goldblum, Randall M.

AU - Forman, Phillip M.

AU - Dupree, Elton

AU - Storey, Wray D.

AU - Goldman, Armond S.

PY - 1973/9/8

Y1 - 1973/9/8

N2 - The case of a male with a late-onset type of combined immunodeficiency and a chronic progressive encephalopathy is reported. In this case serum IgM was undetected but cerebrospinal-fluid (C.S.F.) IgM was demonstrated which appeared to be similar to the normal polymeric form of IgM. This occurrence of IgM in the C.S.F. did not appear to be due to disruption of the blood/brain barrier, since other large-molecular-weight serum-proteins such as alpha-2-macroglobulins and fibrinogen were absent from the C.S.F. Therefore, it appears that the C.S.F. IgM may have been produced by lymphoid cells in the brain.

AB - The case of a male with a late-onset type of combined immunodeficiency and a chronic progressive encephalopathy is reported. In this case serum IgM was undetected but cerebrospinal-fluid (C.S.F.) IgM was demonstrated which appeared to be similar to the normal polymeric form of IgM. This occurrence of IgM in the C.S.F. did not appear to be due to disruption of the blood/brain barrier, since other large-molecular-weight serum-proteins such as alpha-2-macroglobulins and fibrinogen were absent from the C.S.F. Therefore, it appears that the C.S.F. IgM may have been produced by lymphoid cells in the brain.

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CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY

Abstract

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