CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY

Ralph A. Lord, Randall M. Goldblum, Phillip M. Forman, Elton Dupree, Wray D. Storey, Armond S. Goldman

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The case of a male with a late-onset type of combined immunodeficiency and a chronic progressive encephalopathy is reported. In this case serum IgM was undetected but cerebrospinal-fluid (C.S.F.) IgM was demonstrated which appeared to be similar to the normal polymeric form of IgM. This occurrence of IgM in the C.S.F. did not appear to be due to disruption of the blood/brain barrier, since other large-molecular-weight serum-proteins such as alpha-2-macroglobulins and fibrinogen were absent from the C.S.F. Therefore, it appears that the C.S.F. IgM may have been produced by lymphoid cells in the brain.

Original languageEnglish (US)
Pages (from-to)528-529
Number of pages2
JournalThe Lancet
Volume302
Issue number7828
DOIs
StatePublished - Sep 8 1973

ASJC Scopus subject areas

  • Medicine(all)

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    Lord, R. A., Goldblum, R. M., Forman, P. M., Dupree, E., Storey, W. D., & Goldman, A. S. (1973). CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY. The Lancet, 302(7828), 528-529. https://doi.org/10.1016/S0140-6736(73)92349-0