CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY

RalphA Lord, RandallM Goldblum, PhillipM Forman, Elton Dupree, WrayD Storey, ArmondS Goldman

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The case of a male with a late-onset type of combined immunodeficiency and a chronic progressive encephalopathy is reported. In this case serum IgM was undetected but cerebrospinal-fluid (C.S.F.) IgM was demonstrated which appeared to be similar to the normal polymeric form of IgM. This occurrence of IgM in the C.S.F. did not appear to be due to disruption of the blood/brain barrier, since other large-molecular-weight serum-proteins such as alpha-2-macroglobulins and fibrinogen were absent from the C.S.F. Therefore, it appears that the C.S.F. IgM may have been produced by lymphoid cells in the brain.

Original languageEnglish (US)
Pages (from-to)528-529
Number of pages2
JournalThe Lancet
Volume302
Issue number7828
DOIs
StatePublished - Sep 8 1973

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Immunoglobulin M
Cerebrospinal Fluid
Chronic Brain Damage
alpha-Macroglobulins
Blood-Brain Barrier
Fibrinogen
Blood Proteins
Molecular Weight
Lymphocytes
Brain
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lord, R., Goldblum, R., Forman, P., Dupree, E., Storey, W., & Goldman, A. (1973). CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY. The Lancet, 302(7828), 528-529. https://doi.org/10.1016/S0140-6736(73)92349-0

CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY. / Lord, RalphA; Goldblum, RandallM; Forman, PhillipM; Dupree, Elton; Storey, WrayD; Goldman, ArmondS.

In: The Lancet, Vol. 302, No. 7828, 08.09.1973, p. 528-529.

Research output: Contribution to journalArticle

Lord, R, Goldblum, R, Forman, P, Dupree, E, Storey, W & Goldman, A 1973, 'CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY', The Lancet, vol. 302, no. 7828, pp. 528-529. https://doi.org/10.1016/S0140-6736(73)92349-0
Lord R, Goldblum R, Forman P, Dupree E, Storey W, Goldman A. CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY. The Lancet. 1973 Sep 8;302(7828):528-529. https://doi.org/10.1016/S0140-6736(73)92349-0
Lord, RalphA ; Goldblum, RandallM ; Forman, PhillipM ; Dupree, Elton ; Storey, WrayD ; Goldman, ArmondS. / CEREBROSPINAL-FLUID IgM IN THE ABSENCE OF SERUM-IgM IN COMBINED IMMUNODEFICIENCY. In: The Lancet. 1973 ; Vol. 302, No. 7828. pp. 528-529.
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