Certified cell lines of rat origin appear free of infection with Hantavirus

James LeDuc, G. A. Smith, M. Macy, R. J. Hay

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The existence of hantaviruses as adventitious agents in cell cultures of rat origin or antibody-secreting cells could pose a health hazard to humans as well as a potential confounding variable during experimentation. Realizing this, we set out to determine if hantaviruses were present in certified cell lines of rat origin housed at the ATCC (Rockville, Md), the official American repository for such cell lines. Although all cell lines tested appeared to be free of adventitious hantaviruses, the well-documented problems of the arenavirus lymphocytic choriomeningitis virus in mice, hamsters, and assorted cell lines, and the biologic similarities between arenaviruses and hantaviruses further justify our screening efforts and support such prudence in the future.

Original languageEnglish (US)
Pages (from-to)1082-1083
Number of pages2
JournalJournal of Infectious Diseases
Volume152
Issue number5
StatePublished - 1985
Externally publishedYes

Fingerprint

Hantavirus Infections
Hantavirus
Arenavirus
Cell Line
Lymphocytic choriomeningitis virus
Antibody-Producing Cells
Confounding Factors (Epidemiology)
Cricetinae
Cell Culture Techniques
Health

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Certified cell lines of rat origin appear free of infection with Hantavirus. / LeDuc, James; Smith, G. A.; Macy, M.; Hay, R. J.

In: Journal of Infectious Diseases, Vol. 152, No. 5, 1985, p. 1082-1083.

Research output: Contribution to journalArticle

LeDuc, James ; Smith, G. A. ; Macy, M. ; Hay, R. J. / Certified cell lines of rat origin appear free of infection with Hantavirus. In: Journal of Infectious Diseases. 1985 ; Vol. 152, No. 5. pp. 1082-1083.
@article{12ba67f64354479687a08594f0663ccd,
title = "Certified cell lines of rat origin appear free of infection with Hantavirus",
abstract = "The existence of hantaviruses as adventitious agents in cell cultures of rat origin or antibody-secreting cells could pose a health hazard to humans as well as a potential confounding variable during experimentation. Realizing this, we set out to determine if hantaviruses were present in certified cell lines of rat origin housed at the ATCC (Rockville, Md), the official American repository for such cell lines. Although all cell lines tested appeared to be free of adventitious hantaviruses, the well-documented problems of the arenavirus lymphocytic choriomeningitis virus in mice, hamsters, and assorted cell lines, and the biologic similarities between arenaviruses and hantaviruses further justify our screening efforts and support such prudence in the future.",
author = "James LeDuc and Smith, {G. A.} and M. Macy and Hay, {R. J.}",
year = "1985",
language = "English (US)",
volume = "152",
pages = "1082--1083",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Certified cell lines of rat origin appear free of infection with Hantavirus

AU - LeDuc, James

AU - Smith, G. A.

AU - Macy, M.

AU - Hay, R. J.

PY - 1985

Y1 - 1985

N2 - The existence of hantaviruses as adventitious agents in cell cultures of rat origin or antibody-secreting cells could pose a health hazard to humans as well as a potential confounding variable during experimentation. Realizing this, we set out to determine if hantaviruses were present in certified cell lines of rat origin housed at the ATCC (Rockville, Md), the official American repository for such cell lines. Although all cell lines tested appeared to be free of adventitious hantaviruses, the well-documented problems of the arenavirus lymphocytic choriomeningitis virus in mice, hamsters, and assorted cell lines, and the biologic similarities between arenaviruses and hantaviruses further justify our screening efforts and support such prudence in the future.

AB - The existence of hantaviruses as adventitious agents in cell cultures of rat origin or antibody-secreting cells could pose a health hazard to humans as well as a potential confounding variable during experimentation. Realizing this, we set out to determine if hantaviruses were present in certified cell lines of rat origin housed at the ATCC (Rockville, Md), the official American repository for such cell lines. Although all cell lines tested appeared to be free of adventitious hantaviruses, the well-documented problems of the arenavirus lymphocytic choriomeningitis virus in mice, hamsters, and assorted cell lines, and the biologic similarities between arenaviruses and hantaviruses further justify our screening efforts and support such prudence in the future.

UR - http://www.scopus.com/inward/record.url?scp=0022353881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022353881&partnerID=8YFLogxK

M3 - Article

VL - 152

SP - 1082

EP - 1083

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 5

ER -