Cervix Stromal Cells and the Progesterone Receptor A Isoform Mediate Effects of Progesterone for Prepartum Remodeling

Anne C. Heuerman, Trevor T. Hollinger, Ramkumar Menon, Sam Mesiano, Steven M. Yellon

Research output: Contribution to journalArticle

Abstract

The prepartum transition from a soft to ripening cervix is an inflammatory process that occurs well before birth when systemic progesterone is near peak concentration. This 2-part study first determined that stromal fibroblasts but not macrophages in the cervix have progesterone receptors (PRs). Neither the number of PR cells in cervix sections nor the relative abundance or ratio of nuclear PR isoforms (PR-A/PR-B) were diminished in mice between day 15 of pregnancy and term. Second in mice lacking PR-B (Pgrtm20mc), the number of cells that expressed the PR-A isoform were maintained during this period of prepartum cervix remodeling. Thus, progesterone effects to sustain pregnancy, as well as soften and ripen the cervix, are mediated by a stable stromal cell population that expresses PR-A and, through interactions with resident macrophages, are likely to mediate inflammatory ripening processes in preparation for birth.

Original languageEnglish (US)
JournalReproductive Sciences
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Stromal Cells
Cervix Uteri
Progesterone
Protein Isoforms
Progesterone Receptors
Macrophages
Parturition
Pregnancy
Cytoplasmic and Nuclear Receptors
Fibroblasts
Cell Count
progesterone receptor A
Population
progesterone receptor B

Keywords

  • cervix
  • collagen degradation
  • macrophage
  • parturition
  • Pgr mice
  • ripening

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Cervix Stromal Cells and the Progesterone Receptor A Isoform Mediate Effects of Progesterone for Prepartum Remodeling. / Heuerman, Anne C.; Hollinger, Trevor T.; Menon, Ramkumar; Mesiano, Sam; Yellon, Steven M.

In: Reproductive Sciences, 01.01.2019.

Research output: Contribution to journalArticle

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