Cetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial

J. Andrew Grant, Christopher F. Nicodemus, Steven R. Findlay, M. Michael Glovsky, Jay Grossman, Harold Kaiser, Eli O. Meltzer, Don Q. Mitchell, David Pearlman, John Selner, Guy Settipane, William Silvers

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Objective: This study explored the safety and efficacy of cetirizine for treatment of allergic rhinitis and asthma. Methods: Daily treatment for 6 weeks with cetirizine 10 mg (93 patients) was compared with placebo treatment (93 patients) in a randomized, double-blind parallel study of patients with allergic rhinitis and asthma. This multicenter study was started just before onset of the fall pollen season. Rhinitis and asthma symptoms were assessed twice daily; spirometry was performed weekly. Results: Placebo-treated patients experienced a worsening of rhinitis symptoms from baseline throughout the study, whereas cetirizine-treated patients had a significant improvement in rhinitis symptoms at week 1, which was maintained after onset of the pollen season. Asthma symptoms in the cetirizine group improved from baseline at week 1; symptoms were significantly better than in the placebo group for 5 of 6 weeks of the study. Pulmonary function did not worsen in patients taking cetirizine or placebo; there were no differences between treatments as determined by spirometry. Albuterol use was less frequent in the cetirizine-treated patients for every week of the study, but differences did not reach significance. Pseudoephedrine use was similar in both groups. More cetirizine-treated patients (90%) completed the trial than did placebo-treated patients (74%). Both treatments were well tolerated. Conclusion: Cetirizine 10 mg daily is safe and effective in relieving both upper and lower respiratory tract symptoms in patients with seasonal allergic rhinitis and concomitant asthma. (J ALLERGY CLIN IMMUNOL 1995;95:923-32.).

Original languageEnglish (US)
Pages (from-to)923-932
Number of pages10
JournalThe Journal of Allergy and Clinical Immunology
Volume95
Issue number5
DOIs
StatePublished - 1995

Fingerprint

Cetirizine
Rhinitis
Asthma
Randomized Controlled Trials
Placebos
Spirometry
Pollen
Pseudoephedrine
Seasonal Allergic Rhinitis
Albuterol
Therapeutics
Double-Blind Method
Respiratory System
Multicenter Studies

Keywords

  • Allergic rhinitis
  • antihistamines
  • asthma
  • cetirizine
  • histamine
  • histamine-receptor antagonists
  • placebo
  • prophylaxis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Cetirizine in patients with seasonal rhinitis and concomitant asthma : prospective, randomized, placebo-controlled trial. / Grant, J. Andrew; Nicodemus, Christopher F.; Findlay, Steven R.; Glovsky, M. Michael; Grossman, Jay; Kaiser, Harold; Meltzer, Eli O.; Mitchell, Don Q.; Pearlman, David; Selner, John; Settipane, Guy; Silvers, William.

In: The Journal of Allergy and Clinical Immunology, Vol. 95, No. 5, 1995, p. 923-932.

Research output: Contribution to journalArticle

Grant, JA, Nicodemus, CF, Findlay, SR, Glovsky, MM, Grossman, J, Kaiser, H, Meltzer, EO, Mitchell, DQ, Pearlman, D, Selner, J, Settipane, G & Silvers, W 1995, 'Cetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial', The Journal of Allergy and Clinical Immunology, vol. 95, no. 5, pp. 923-932. https://doi.org/10.1016/S0091-6749(95)70090-0
Grant, J. Andrew ; Nicodemus, Christopher F. ; Findlay, Steven R. ; Glovsky, M. Michael ; Grossman, Jay ; Kaiser, Harold ; Meltzer, Eli O. ; Mitchell, Don Q. ; Pearlman, David ; Selner, John ; Settipane, Guy ; Silvers, William. / Cetirizine in patients with seasonal rhinitis and concomitant asthma : prospective, randomized, placebo-controlled trial. In: The Journal of Allergy and Clinical Immunology. 1995 ; Vol. 95, No. 5. pp. 923-932.
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abstract = "Objective: This study explored the safety and efficacy of cetirizine for treatment of allergic rhinitis and asthma. Methods: Daily treatment for 6 weeks with cetirizine 10 mg (93 patients) was compared with placebo treatment (93 patients) in a randomized, double-blind parallel study of patients with allergic rhinitis and asthma. This multicenter study was started just before onset of the fall pollen season. Rhinitis and asthma symptoms were assessed twice daily; spirometry was performed weekly. Results: Placebo-treated patients experienced a worsening of rhinitis symptoms from baseline throughout the study, whereas cetirizine-treated patients had a significant improvement in rhinitis symptoms at week 1, which was maintained after onset of the pollen season. Asthma symptoms in the cetirizine group improved from baseline at week 1; symptoms were significantly better than in the placebo group for 5 of 6 weeks of the study. Pulmonary function did not worsen in patients taking cetirizine or placebo; there were no differences between treatments as determined by spirometry. Albuterol use was less frequent in the cetirizine-treated patients for every week of the study, but differences did not reach significance. Pseudoephedrine use was similar in both groups. More cetirizine-treated patients (90{\%}) completed the trial than did placebo-treated patients (74{\%}). Both treatments were well tolerated. Conclusion: Cetirizine 10 mg daily is safe and effective in relieving both upper and lower respiratory tract symptoms in patients with seasonal allergic rhinitis and concomitant asthma. (J ALLERGY CLIN IMMUNOL 1995;95:923-32.).",
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AU - Glovsky, M. Michael

AU - Grossman, Jay

AU - Kaiser, Harold

AU - Meltzer, Eli O.

AU - Mitchell, Don Q.

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AU - Selner, John

AU - Settipane, Guy

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N2 - Objective: This study explored the safety and efficacy of cetirizine for treatment of allergic rhinitis and asthma. Methods: Daily treatment for 6 weeks with cetirizine 10 mg (93 patients) was compared with placebo treatment (93 patients) in a randomized, double-blind parallel study of patients with allergic rhinitis and asthma. This multicenter study was started just before onset of the fall pollen season. Rhinitis and asthma symptoms were assessed twice daily; spirometry was performed weekly. Results: Placebo-treated patients experienced a worsening of rhinitis symptoms from baseline throughout the study, whereas cetirizine-treated patients had a significant improvement in rhinitis symptoms at week 1, which was maintained after onset of the pollen season. Asthma symptoms in the cetirizine group improved from baseline at week 1; symptoms were significantly better than in the placebo group for 5 of 6 weeks of the study. Pulmonary function did not worsen in patients taking cetirizine or placebo; there were no differences between treatments as determined by spirometry. Albuterol use was less frequent in the cetirizine-treated patients for every week of the study, but differences did not reach significance. Pseudoephedrine use was similar in both groups. More cetirizine-treated patients (90%) completed the trial than did placebo-treated patients (74%). Both treatments were well tolerated. Conclusion: Cetirizine 10 mg daily is safe and effective in relieving both upper and lower respiratory tract symptoms in patients with seasonal allergic rhinitis and concomitant asthma. (J ALLERGY CLIN IMMUNOL 1995;95:923-32.).

AB - Objective: This study explored the safety and efficacy of cetirizine for treatment of allergic rhinitis and asthma. Methods: Daily treatment for 6 weeks with cetirizine 10 mg (93 patients) was compared with placebo treatment (93 patients) in a randomized, double-blind parallel study of patients with allergic rhinitis and asthma. This multicenter study was started just before onset of the fall pollen season. Rhinitis and asthma symptoms were assessed twice daily; spirometry was performed weekly. Results: Placebo-treated patients experienced a worsening of rhinitis symptoms from baseline throughout the study, whereas cetirizine-treated patients had a significant improvement in rhinitis symptoms at week 1, which was maintained after onset of the pollen season. Asthma symptoms in the cetirizine group improved from baseline at week 1; symptoms were significantly better than in the placebo group for 5 of 6 weeks of the study. Pulmonary function did not worsen in patients taking cetirizine or placebo; there were no differences between treatments as determined by spirometry. Albuterol use was less frequent in the cetirizine-treated patients for every week of the study, but differences did not reach significance. Pseudoephedrine use was similar in both groups. More cetirizine-treated patients (90%) completed the trial than did placebo-treated patients (74%). Both treatments were well tolerated. Conclusion: Cetirizine 10 mg daily is safe and effective in relieving both upper and lower respiratory tract symptoms in patients with seasonal allergic rhinitis and concomitant asthma. (J ALLERGY CLIN IMMUNOL 1995;95:923-32.).

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