Challenges and future prospects of antibiotic therapy: From peptides to phages utilization

Santi M. Mandal, Anupam Roy, Ananta K. Ghosh, Tapas Hazra, Amit Basak, Octavio L. Franco

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Bacterial infections are raising serious concern across the globe. The effectiveness of conventional antibiotics is decreasing due to global emergence of multi-drug-resistant (MDR) bacterial pathogens. This process seems to be primarily caused by an indiscriminate and inappropriate use of antibiotics in non-infected patients and in the food industry. New classes of antibiotics with different actions against MDR pathogens need to be developed urgently. In this context, this review focuses on several ways and future directions to search for the next generation of safe and effective antibiotics compounds including antimicrobial peptides, phage therapy, phytochemicals, metalloantibiotics, lipopolysaccharide, and efflux pump inhibitors to control the infections caused by MDR pathogens.

Original languageEnglish (US)
Article number105
JournalFrontiers in Pharmacology
Volume5 MAY
DOIs
StatePublished - 2014

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Bacteriophages
Anti-Bacterial Agents
Peptides
Pharmaceutical Preparations
Food Industry
Phytochemicals
Therapeutics
Infection Control
Bacterial Infections
Lipopolysaccharides

Keywords

  • Antibiotics
  • Infection control
  • Multi-drug-resistant pathogens

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Challenges and future prospects of antibiotic therapy : From peptides to phages utilization. / Mandal, Santi M.; Roy, Anupam; Ghosh, Ananta K.; Hazra, Tapas; Basak, Amit; Franco, Octavio L.

In: Frontiers in Pharmacology, Vol. 5 MAY, 105, 2014.

Research output: Contribution to journalArticle

Mandal, Santi M. ; Roy, Anupam ; Ghosh, Ananta K. ; Hazra, Tapas ; Basak, Amit ; Franco, Octavio L. / Challenges and future prospects of antibiotic therapy : From peptides to phages utilization. In: Frontiers in Pharmacology. 2014 ; Vol. 5 MAY.
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