Challenges and new horizons in the management of advanced basal cell carcinoma: A UK perspective

J. T. Lear, C. Corner, P. Dziewulski, K. Fife, G. L. Ross, S. Varma, C. A. Harwood

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations


Basal cell carcinoma (BCC) is a common malignancy with a good prognosis in the majority of cases. However, some BCC patients develop a more advanced disease that poses significant management challenges. Such cases include locally advanced, recurrent or metastatic BCC, or tumours that occur in anatomical sites where surgical treatment would result in significant deformity. Until recently, treatment options for these patients have been limited, but increased understanding of the molecular basis of BCC has enabled potential therapies, such as hedgehog signalling pathway inhibitors, to be developed. A clear definition of advanced BCC as a distinct disease entity and formal management guidelines have not previously been published, presumably because of the rarity, heterogeneity and lack of treatment options available for the disease. Here we provide a UK perspective from a multidisciplinary group of experts involved in the treatment of complex cases of BCC, addressing the key challenges associated with the perceived definition and management of the disease. With new treatments on the horizon, we further propose a definition for advanced BCC that may be used as a guide for healthcare professionals involved in disease diagnosis and management.

Original languageEnglish (US)
Pages (from-to)1476-1481
Number of pages6
JournalBritish Journal of Cancer
Issue number8
StatePublished - Oct 14 2014
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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