Challenges in IBD Research: Novel Technologies

Manish Dhyani, Nitin Joshi, Willem A. Bemelman, Michael S. Gee, Vijay Yajnik, André D'Hoore, Giovanni Traverso, Mark Donowitz, Gustavo Mostoslavsky, Timothy K. Lu, Neil Lineberry, Heiko G. Niessen, Dan Peer, Jonathan Braun, Conor P. Delaney, Marla C. Dubinsky, Ashley Guillory, Maria Pereira, Nataly Shtraizent, Gerard HonigDavid Brent Polk, Andrés Hurtado-Lorenzo, Jeffrey M. Karp, Fabrizio Michelassi

Research output: Contribution to journalArticle

Abstract

Novel technologies is part of five focus areas of the Challenges in IBD research document, which also includes preclinical human IBD mechanisms, environmental triggers, precision medicine and pragmatic clinical research. The Challenges in IBD research document provides a comprehensive overview of current gaps in inflammatory bowel diseases (IBD) research and delivers actionable approaches to address them. It is the result of a multidisciplinary input from scientists, clinicians, patients, and funders, and represents a valuable resource for patient centric research prioritization. In particular, the novel technologies section is focused on prioritizing unmet clinical needs in IBD that will benefit from novel technologies applied to: 1) non-invasive detection and monitoring of active inflammation and assessment of treatment response; 2) mucosal targeted drug delivery systems; and 3) prevention of post-operative septic complications and treatment of fistulizing complications. Proposed approaches include development of multiparametric imaging modalities and biosensors, to enable non invasive or minimally invasive detection of pro-inflammatory signals to monitor disease activity and treatment responses. Additionally, technologies for local drug delivery to control unremitting disease and increase treatment efficacy while decreasing systemic exposure are also proposed. Finally, research on biopolymers and other sealant technologies to promote post-surgical healing; and devices to control anastomotic leakage and prevent post-surgical complications and recurrences are also needed.

Original languageEnglish (US)
Pages (from-to)S24-S30
JournalInflammatory bowel diseases
Volume25
Issue number2
DOIs
StatePublished - May 16 2019

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Keywords

  • anastomosis
  • Crohn’s disease
  • drug delivery
  • fistula
  • non-invasive imaging
  • radiology
  • sepsis
  • surgery
  • ulcerative colitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

Cite this

Dhyani, M., Joshi, N., Bemelman, W. A., Gee, M. S., Yajnik, V., D'Hoore, A., Traverso, G., Donowitz, M., Mostoslavsky, G., Lu, T. K., Lineberry, N., Niessen, H. G., Peer, D., Braun, J., Delaney, C. P., Dubinsky, M. C., Guillory, A., Pereira, M., Shtraizent, N., ... Michelassi, F. (2019). Challenges in IBD Research: Novel Technologies. Inflammatory bowel diseases, 25(2), S24-S30. https://doi.org/10.1093/ibd/izz077