Changes in body temperature markedly affect striatal dopamine release and metabolism: an in vivo study

T. Brannan, J. Martínez-Tica, M. D. Yahr

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Dopamine release and metabolism in the corpus striatum increased markedly when the core body temperature of anesthetized rats was increased from 35 ° to 41 °C while temperatures below 34 ° were associated with a marked attenuation of dopamine release. These observations may have clinical relevance in cases where alterations in body temperature are associated with extrapyramidal dysfunction.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalJournal of Neural Transmission
Volume89
Issue number3
DOIs
StatePublished - Oct 1 1992

Keywords

  • Dopamine
  • Parkinson's disease
  • body temperature
  • cerebral microdialysis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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