Changes in lectin, GAP-43 and neuropeptide staining in the rat superficial dorsal horn following experimental peripheral neuropathy

Adrian A. Cameron, Kenneth D. Cliffer, Patrick M. Dougherty, William D. Willis, Susan M. Carlton

    Research output: Contribution to journalArticle

    80 Citations (Scopus)

    Abstract

    The density and distribution of reactivity for two lectins (soybean agglutinin (SBA) and RL-29), growth associated protein-43 (GAP-43) and the neuropeptides substance P and calcitonin gene-related peptide were analyzed in the spinal cord dorsal horn of rats with an experimental peripheral neuropathy. Twenty-eight days postsurgery, the density of label for RL-29 and GAP-43 was increased in laminae I and II on the experimental compared to the control side. In contrast, the density of neuropeptide label was decreased in the same region. Furthermore, on the experimental side, the distribution of both SBA and RL-29 reactivity was increased, extending into lamina III. We hypothesize that the increases in density and distribution of reactivity for the lectins and GAP-43, as well as the decreases in neuropeptide reactivity, reflect injury-induced regenerative changes in primary afferent terminals.

    Original languageEnglish (US)
    Pages (from-to)249-252
    Number of pages4
    JournalNeuroscience Letters
    Volume131
    Issue number2
    DOIs
    StatePublished - Oct 14 1991

    Fingerprint

    GAP-43 Protein
    Peripheral Nervous System Diseases
    Neuropeptides
    Lectins
    Staining and Labeling
    Substantia Gelatinosa
    Calcitonin Gene-Related Peptide
    Substance P
    Wounds and Injuries
    Spinal Cord Dorsal Horn
    soybean lectin

    Keywords

    • Calcitonin gene-related peptide
    • Plasticity
    • Primary afferent
    • RL-29
    • Soybean agglutinin
    • Substance P

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Changes in lectin, GAP-43 and neuropeptide staining in the rat superficial dorsal horn following experimental peripheral neuropathy. / Cameron, Adrian A.; Cliffer, Kenneth D.; Dougherty, Patrick M.; Willis, William D.; Carlton, Susan M.

    In: Neuroscience Letters, Vol. 131, No. 2, 14.10.1991, p. 249-252.

    Research output: Contribution to journalArticle

    Cameron, Adrian A. ; Cliffer, Kenneth D. ; Dougherty, Patrick M. ; Willis, William D. ; Carlton, Susan M. / Changes in lectin, GAP-43 and neuropeptide staining in the rat superficial dorsal horn following experimental peripheral neuropathy. In: Neuroscience Letters. 1991 ; Vol. 131, No. 2. pp. 249-252.
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    AU - Cliffer, Kenneth D.

    AU - Dougherty, Patrick M.

    AU - Willis, William D.

    AU - Carlton, Susan M.

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