Changes in lectin, GAP-43 and neuropeptide staining in the rat superficial dorsal horn following experimental peripheral neuropathy

Adrian A. Cameron, Kenneth D. Cliffer, Patrick M. Dougherty, William D. Willis, Susan M. Carlton

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

The density and distribution of reactivity for two lectins (soybean agglutinin (SBA) and RL-29), growth associated protein-43 (GAP-43) and the neuropeptides substance P and calcitonin gene-related peptide were analyzed in the spinal cord dorsal horn of rats with an experimental peripheral neuropathy. Twenty-eight days postsurgery, the density of label for RL-29 and GAP-43 was increased in laminae I and II on the experimental compared to the control side. In contrast, the density of neuropeptide label was decreased in the same region. Furthermore, on the experimental side, the distribution of both SBA and RL-29 reactivity was increased, extending into lamina III. We hypothesize that the increases in density and distribution of reactivity for the lectins and GAP-43, as well as the decreases in neuropeptide reactivity, reflect injury-induced regenerative changes in primary afferent terminals.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalNeuroscience Letters
Volume131
Issue number2
DOIs
StatePublished - Oct 14 1991
Externally publishedYes

Keywords

  • Calcitonin gene-related peptide
  • Plasticity
  • Primary afferent
  • RL-29
  • Soybean agglutinin
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Changes in lectin, GAP-43 and neuropeptide staining in the rat superficial dorsal horn following experimental peripheral neuropathy'. Together they form a unique fingerprint.

Cite this