Abstract
The aim of the study was to characterize the nature of the formaldehyde-induced nasal response consisting in symptoms of rhinitis and changes in nasal lavage fluid. Eleven healthy subjects and nine patients with specific skin sensitization were provoked in a toxicological chamber with formaldehyde at a dose of 0.5 mg/m3 over 2 h. Nasal lavage was performed prior to and immediately after provocation and 4 and 18 h later. Provocation with formaldehyde caused transient symptoms of rhinitis and prolonged changes in nasal washings. There were increases in the number and proportion of eosinophils and elevated albumin and total protein levels in nasal lavage fluid 4 and 18 h after provocation. No difference in the nasal response to formaldehyde was found between patients with skin sensitization and healthy subjects. These data confirm the irritative effects of formaldehyde and are also suggestive of nonspecific proinflammatory properties when formaldehyde is inhaled at a low (0.5 mg/m3) dose.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 515-519 |
| Number of pages | 5 |
| Journal | International Archives of Occupational and Environmental Health |
| Volume | 64 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 1993 |
| Externally published | Yes |
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Keywords
- Eosinophils
- Formaldehyd
- Nasal lavage
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
Cite this
Changes in nasal lavage fluid due to formaldehyde inhalation. / Pazdrak, Konrad; Górski, Pawel; Krakowiak, Anna; Ruta, Urszula.
In: International Archives of Occupational and Environmental Health, Vol. 64, No. 7, 04.1993, p. 515-519.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in nasal lavage fluid due to formaldehyde inhalation
AU - Pazdrak, Konrad
AU - Górski, Pawel
AU - Krakowiak, Anna
AU - Ruta, Urszula
PY - 1993/4
Y1 - 1993/4
N2 - The aim of the study was to characterize the nature of the formaldehyde-induced nasal response consisting in symptoms of rhinitis and changes in nasal lavage fluid. Eleven healthy subjects and nine patients with specific skin sensitization were provoked in a toxicological chamber with formaldehyde at a dose of 0.5 mg/m3 over 2 h. Nasal lavage was performed prior to and immediately after provocation and 4 and 18 h later. Provocation with formaldehyde caused transient symptoms of rhinitis and prolonged changes in nasal washings. There were increases in the number and proportion of eosinophils and elevated albumin and total protein levels in nasal lavage fluid 4 and 18 h after provocation. No difference in the nasal response to formaldehyde was found between patients with skin sensitization and healthy subjects. These data confirm the irritative effects of formaldehyde and are also suggestive of nonspecific proinflammatory properties when formaldehyde is inhaled at a low (0.5 mg/m3) dose.
AB - The aim of the study was to characterize the nature of the formaldehyde-induced nasal response consisting in symptoms of rhinitis and changes in nasal lavage fluid. Eleven healthy subjects and nine patients with specific skin sensitization were provoked in a toxicological chamber with formaldehyde at a dose of 0.5 mg/m3 over 2 h. Nasal lavage was performed prior to and immediately after provocation and 4 and 18 h later. Provocation with formaldehyde caused transient symptoms of rhinitis and prolonged changes in nasal washings. There were increases in the number and proportion of eosinophils and elevated albumin and total protein levels in nasal lavage fluid 4 and 18 h after provocation. No difference in the nasal response to formaldehyde was found between patients with skin sensitization and healthy subjects. These data confirm the irritative effects of formaldehyde and are also suggestive of nonspecific proinflammatory properties when formaldehyde is inhaled at a low (0.5 mg/m3) dose.
KW - Eosinophils
KW - Formaldehyd
KW - Nasal lavage
UR - http://www.scopus.com/inward/record.url?scp=0027167640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027167640&partnerID=8YFLogxK
U2 - 10.1007/BF00381101
DO - 10.1007/BF00381101
M3 - Article
VL - 64
SP - 515
EP - 519
JO - International Archives of Occupational and Environmental Health
JF - International Archives of Occupational and Environmental Health
SN - 0340-0131
IS - 7
ER -