Changes in nasal lavage fluid due to formaldehyde inhalation

Konrad Pazdrak, Pawel Górski, Anna Krakowiak, Urszula Ruta

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The aim of the study was to characterize the nature of the formaldehyde-induced nasal response consisting in symptoms of rhinitis and changes in nasal lavage fluid. Eleven healthy subjects and nine patients with specific skin sensitization were provoked in a toxicological chamber with formaldehyde at a dose of 0.5 mg/m3 over 2 h. Nasal lavage was performed prior to and immediately after provocation and 4 and 18 h later. Provocation with formaldehyde caused transient symptoms of rhinitis and prolonged changes in nasal washings. There were increases in the number and proportion of eosinophils and elevated albumin and total protein levels in nasal lavage fluid 4 and 18 h after provocation. No difference in the nasal response to formaldehyde was found between patients with skin sensitization and healthy subjects. These data confirm the irritative effects of formaldehyde and are also suggestive of nonspecific proinflammatory properties when formaldehyde is inhaled at a low (0.5 mg/m3) dose.

Original languageEnglish (US)
Pages (from-to)515-519
Number of pages5
JournalInternational Archives of Occupational and Environmental Health
Volume64
Issue number7
DOIs
StatePublished - Apr 1993
Externally publishedYes

Fingerprint

Nasal Lavage Fluid
Inhalation
Formaldehyde
Rhinitis
Nose
Healthy Volunteers
Nasal Lavage
Skin
Eosinophils
Toxicology
Albumins

Keywords

  • Eosinophils
  • Formaldehyd
  • Nasal lavage

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Changes in nasal lavage fluid due to formaldehyde inhalation. / Pazdrak, Konrad; Górski, Pawel; Krakowiak, Anna; Ruta, Urszula.

In: International Archives of Occupational and Environmental Health, Vol. 64, No. 7, 04.1993, p. 515-519.

Research output: Contribution to journalArticle

Pazdrak, Konrad ; Górski, Pawel ; Krakowiak, Anna ; Ruta, Urszula. / Changes in nasal lavage fluid due to formaldehyde inhalation. In: International Archives of Occupational and Environmental Health. 1993 ; Vol. 64, No. 7. pp. 515-519.
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